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anti-TUBG1 antibody :: Rabbit Tubulin-gamma Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301666
Immunohistochemistry (IHC)
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tubulin-gamma (TUBG1), Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human Tubulin-gamma Polyclonal Antibody

 Product Gene Name   

anti-TUBG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191135
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Bovine, Dog, Frog, Mouse, Rat
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from C-terminus of human tubulin gamma protein.
 Control Tissue    Colon Carcinoma
 Cellular Localization    Cytoplasm
 Entrez Gene Code    7283
 Pathway    Cytoskeletal Proteins
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-TUBG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TUBG1 antibody

   Tubulin gamma, an essential structural protein for cell growth, organizes microtubule arrays in the nucleus and cytoplasm. Tubulin gamma-depleted cells fail to form functional spindles and arrest during nuclear division. Tubulin gamma associates with spindle body components Spc97 and Spc98 to form the tubulin gamma complex. The phosphorylation of tubulin gamma at Tyr445 plays a regulatory role in microtubule formation. The incidence rate for this phosphorylation event peaks during G1.
 Applications Tested/Suitable for anti-TUBG1 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-TUBG1 antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Colon Carcinoma
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 Immunohistochemistry (IHC) of anti-TUBG1 antibody    Human colon carcinoma stained with anti-tubulin gamma antibody
anti-TUBG1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TUBG1. It may not necessarily be applicable to this product.
 NCBI GI #    31543831
 NCBI GeneID    7283
 NCBI Accession #    NP_001061.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001070.4 [Other Products]
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 UniProt Secondary Accession #    Q53X79; Q9BW59 [Other Products]
 UniProt Related Accession #    P23258 [Other Products]
 Molecular Weight    50 kDa [Similar Products]
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 NCBI Official Full Name    tubulin gamma-1 chain
 NCBI Official Synonym Full Names    tubulin, gamma 1
 NCBI Official Symbol    TUBG1 [Similar Products]
 NCBI Official Synonym Symbols   
TUBG; GCP-1; CDCBM4; TUBGCP1
[Similar Products]
 NCBI Protein Information    tubulin gamma-1 chain; gamma-tubulin complex component 1; tubulin, gamma polypeptide
 UniProt Protein Name    Tubulin gamma-1 chain
 UniProt Synonym Protein Names   
Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1
 UniProt Gene Name    TUBG1 [Similar Products]
 UniProt Synonym Gene Names    TUBG; GCP-1 [Similar Products]
 UniProt Entry Name    TBG1_HUMAN
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 NCBI Summary for TUBG1    This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
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 UniProt Comments for TUBG1    TUBG1: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: centriole; centrosome; pericentriolar material; recycling endosome; condensed nuclear chromosome; cytoplasmic microtubule; apical part of cell; nonmotile primary cilium; leading edge; cytoplasm; polar microtubule; cytosol; gamma-tubulin complex

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: metabolic process; organelle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule nucleation; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 4
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 Research Articles on TUBG1    1. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TUBG1 antibodyDiseases associated with anti-TUBG1 antibody
 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with TUBG1 and Nervous System Diseases
 Malformations of Cortical Development Antibodies  >4 publications with TUBG1 and Malformations of Cortical Development
 Microcephaly Antibodies  >2 publications with TUBG1 and Microcephaly
 Multiple Myeloma Antibodies  >1 publications with TUBG1 and Multiple Myeloma
 Carcinoma Antibodies  >1 publications with TUBG1 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with TUBG1 and Breast Neoplasms
Organs/Tissues associated with anti-TUBG1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with TUBG1 and Brain
 Embryonic Tissue Antibodies  >4 publications with TUBG1 and Embryonic Tissue
 Muscle Antibodies  >1 publications with TUBG1 and Muscle
 Lung Antibodies  >1 publications with TUBG1 and Lung
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