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anti-TNFRSF11A antibody :: Rabbit anti-Human Tumor necrosis factor receptor superfamily member 11A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000669
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Tumor necrosis factor receptor superfamily member 11A polyclonal Antibody

 Product Synonym Names    Tumor necrosis factor receptor superfamily member 11A protein; Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD265; TNFRSF11A; RANK
 Product Gene Name   

anti-TNFRSF11A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    174810
 3D Structure    ModBase 3D Structure for Q9Y6Q6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Tumor necrosis factor receptor superfamily member 11A protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7624 / sc-34249 / sc-7626 / sc-7625 / sc-34248 / sc-9072
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TNFRSF11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFRSF11A antibody

   RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na�ve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).

This protein is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells.
 Product Categories/Family for anti-TNFRSF11A antibody    Immunology
 Applications Tested/Suitable for anti-TNFRSF11A antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TNFRSF11A antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-TNFRSF11A antibody    Western blot
All lanes: Tumor necrosis factor receptor superfamily member 11A antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 67,33,37,29,57,65 kDa
Observed band size: 67 kDa,43 kDa

anti-TNFRSF11A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TNFRSF11A. It may not necessarily be applicable to this product.
 NCBI GI #    401015111
 NCBI GeneID    8792
 NCBI Accession #    NP_001257878.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270949.1 [Other Products]
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 UniProt Primary Accession #    Q9Y6Q6 [Other Products]
 UniProt Secondary Accession #    Q59EP9; I4EC36; I4EC38; I4EC39; I7JE63; N0GVH0 [Other Products]
 UniProt Related Accession #    Q9Y6Q6 [Other Products]
 Molecular Weight    64,552 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 11A isoform 2
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily member 11a
 NCBI Official Symbol    TNFRSF11A [Similar Products]
 NCBI Official Synonym Symbols   
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 11A
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 11A
 UniProt Synonym Protein Names   
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF11A [Similar Products]
 UniProt Synonym Gene Names    RANK; ODFR [Similar Products]
 UniProt Entry Name    TNR11_HUMAN
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 NCBI Summary for TNFRSF11A    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
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 UniProt Comments for TNFRSF11A    TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell-cell signaling; circadian thermoregulation; inflammatory response; lymph node development; monocyte chemotaxis; ossification; osteoclast differentiation; positive regulation of cell proliferation; positive regulation of JNK activity; positive regulation of transcription factor activity; regulation of apoptosis; response to cytokine stimulus; response to lipopolysaccharide; response to radiation; signal transduction; tumor necrosis factor-mediated signaling pathway

Disease: Familial Expansile Osteolysis; Osteopetrosis, Autosomal Recessive 7; Paget Disease Of Bone
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 Research Articles on TNFRSF11A    1. RANK/OPG ratio of expression in primary ccRCC is associated with BM.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF11A antibodyPathways associated with anti-TNFRSF11A antibody
 Reference Product  PubMed Publications
 TNFSF11 antibody  >1482 publications with TNFRSF11A and TNFSF11
 TRAF6 antibody  >64 publications with TNFRSF11A and TRAF6
 FOS antibody  >48 publications with TNFRSF11A and FOS
 SRC antibody  >36 publications with TNFRSF11A and SRC
 TRAF2 antibody  >15 publications with TNFRSF11A and TRAF2
 TRAF1 antibody  >8 publications with TNFRSF11A and TRAF1
 TRAF5 antibody  >8 publications with TNFRSF11A and TRAF5
 TRAF3 antibody  >6 publications with TNFRSF11A and TRAF3
 PIGN antibody  >1 publications with TNFRSF11A and PIGN
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-TNFRSF11A antibodyOrgans/Tissues associated with anti-TNFRSF11A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >891 publications with TNFRSF11A and Necrosis
 Inflammation Antibodies  >154 publications with TNFRSF11A and Inflammation
 Cardiovascular Diseases Antibodies  >112 publications with TNFRSF11A and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >65 publications with TNFRSF11A and Breast Neoplasms
 Osteitis Deformans Antibodies  >53 publications with TNFRSF11A and Osteitis Deformans
 Neoplasm Metastasis Antibodies  >44 publications with TNFRSF11A and Neoplasm Metastasis
 Osteosarcoma Antibodies  >33 publications with TNFRSF11A and Osteosarcoma
 Kidney Diseases Antibodies  >24 publications with TNFRSF11A and Kidney Diseases
 Neoplasms, Experimental Antibodies  >23 publications with TNFRSF11A and Neoplasms, Experimental
 Heart Diseases Antibodies  >18 publications with TNFRSF11A and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1404 publications with TNFRSF11A and Bone
 Vascular Antibodies  >81 publications with TNFRSF11A and Vascular
 Skin Antibodies  >23 publications with TNFRSF11A and Skin
 Liver Antibodies  >22 publications with TNFRSF11A and Liver
 Lung Antibodies  >22 publications with TNFRSF11A and Lung
 Brain Antibodies  >21 publications with TNFRSF11A and Brain
 Heart Antibodies  >20 publications with TNFRSF11A and Heart
 Kidney Antibodies  >20 publications with TNFRSF11A and Kidney
 Embryonic Tissue Antibodies  >19 publications with TNFRSF11A and Embryonic Tissue
 Intestine Antibodies  >8 publications with TNFRSF11A and Intestine
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