NP_036872.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
tyrosine 3-monooxygenase
NCBI Official Synonym Full Names
tyrosine hydroxylase
NCBI Official Synonym Symbols
NCBI Protein Information
tyrosine 3-monooxygenase; tyrosine 3-hydroxylase
UniProt Protein Name
Tyrosine 3-monooxygenase
UniProt Synonym Protein Names
Tyrosine 3-hydroxylase
UniProt Synonym Gene Names
UniProt Entry Name
TY3H_RAT
NCBI Summary for TH
catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]
UniProt Comments for TH
Function: Plays an important role in the physiology of adrenergic neurons.
Catalytic activity: L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.
Cofactor: Fe2+ ion.
Enzyme regulation: Phosphorylation leads to an increase in the catalytic activity.
Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
Subunit structure: Homotetramer.
Post-translational modification: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation.
Sequence similarities: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Product References and Citations for anti-TH antibody
• Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043. • Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567. • Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360. • Witkovsky P, Gabriel R, Haycock JW, Meller E (2000) Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina. J Chem Neuroanat 19:105-116. • Xu ZQ, Lew JY, Harada K, Aman K, Goldstein M, Deutch A, Haycock JW, Hokfelt T (1998) Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies. Neurosci 82:727-738
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Pathways associated with anti-TH antibody
Diseases associated with anti-TH antibody
Organs/Tissues associated with anti-TH antibody
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