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anti-TH antibody :: Rabbit Tyrosine Hydroxylase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9600886
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosine Hydroxylase (TH), Polyclonal Antibody

★Popular Item★
 Also Known As   

Phospho-Tyrosine Hydroxylase (Ser40) Antibody

 Product Synonym Names    Dystonia 14; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_HUMAN; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; Tyrosine hydroxylase
 Product Gene Name   

anti-TH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P07101
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-Tyrosine Hydroxylase (Ser40) antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at Serine 40
 Purity/Purification    From purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Serine 40
 Tissue Specificity    Mainly expressed in the brain and adrenal glands.
 Conjugation    Unconjugated
 Epitope    Phospho Ser40
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-TH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TH antibody

   Description: Tyrosine hydroxylase (EC 1.14.16.2) is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
Function: Plays an important role in the physiology of adrenergic neurons.
Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
 Applications Tested/Suitable for anti-TH antibody   

Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-TH antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
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 Western Blot (WB) of anti-TH antibody    Western blot analysis of Tyrosine Hydroxylase phosphorylation expression in RAW264.7 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
anti-TH antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TH antibody    MBS9600886 at 1/200 staining Rat brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-TH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TH antibody    MBS9600886 at 1/200 staining Rat brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-TH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TH antibody    MBS9600886 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-TH antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-TH antibody    Western blot analysis of Phospho-Tyrosine Hydroxylase (Ser40) expression in various lysates
anti-TH antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TH. It may not necessarily be applicable to this product.
 NCBI GI #    88900503
 NCBI GeneID    7054
 NCBI Accession #    NP_000351.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000360.3 [Other Products]
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 UniProt Primary Accession #    P07101 [Other Products]
 UniProt Secondary Accession #    Q0PWM2; Q0PWM3; Q15585; Q15588; Q15589; Q2M3B4; B7ZL70; B7ZL73 [Other Products]
 UniProt Related Accession #    P07101 [Other Products]
 Molecular Weight    Observed: 60 kDa
Predicted: 59 kDa
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 NCBI Official Full Name    tyrosine 3-monooxygenase isoform b
 NCBI Official Synonym Full Names    tyrosine hydroxylase
 NCBI Official Symbol    TH [Similar Products]
 NCBI Official Synonym Symbols   
TYH; DYT14; DYT5b
[Similar Products]
 NCBI Protein Information    tyrosine 3-monooxygenase
 UniProt Protein Name    Tyrosine 3-monooxygenase
 UniProt Synonym Protein Names   
Tyrosine 3-hydroxylase; TH
 UniProt Gene Name    TH [Similar Products]
 UniProt Synonym Gene Names    TYH; TH [Similar Products]
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 NCBI Summary for TH    The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TH    Plays an important role in the physiology of adrenergic neurons.
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 Research Articles on TH    1. It is a genetic risk for Parkinson's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TH antibodyPathways associated with anti-TH antibody
 Reference Product  PubMed Publications
 MAPK3 antibody  >1294 publications with TH and MAPK3
 MAPK1 antibody  >1247 publications with TH and MAPK1
 SNCA antibody  >117 publications with TH and SNCA
 MAPKAPK2 antibody  >68 publications with TH and MAPKAPK2
 YWHAZ antibody  >11 publications with TH and YWHAZ
 YWHAB antibody  >6 publications with TH and YWHAB
 CAMK2G antibody  >5 publications with TH and CAMK2G
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
Diseases associated with anti-TH antibodyOrgans/Tissues associated with anti-TH antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1155571 publications with TH and Neoplasms
 Nervous System Diseases Antibodies  >845925 publications with TH and Nervous System Diseases
 Heart Diseases Antibodies  >465735 publications with TH and Heart Diseases
 Brain Diseases Antibodies  >402056 publications with TH and Brain Diseases
 Pain Antibodies  >306948 publications with TH and Pain
 Kidney Diseases Antibodies  >202332 publications with TH and Kidney Diseases
 Hypertension Antibodies  >166900 publications with TH and Hypertension
 Inflammation Antibodies  >163782 publications with TH and Inflammation
 Drug Toxicity Antibodies  >128138 publications with TH and Drug Toxicity
 Necrosis Antibodies  >106561 publications with TH and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >270193 publications with TH and Brain
 Eye Antibodies  >141187 publications with TH and Eye
 Nerve Antibodies  >122423 publications with TH and Nerve
 Mouth Antibodies  >99951 publications with TH and Mouth
 Pancreas Antibodies  >39845 publications with TH and Pancreas
 Adrenal Gland Antibodies  >19118 publications with TH and Adrenal Gland
 Embryonic Tissue Antibodies  >15985 publications with TH and Embryonic Tissue
 Placenta Antibodies  >8677 publications with TH and Placenta
 Uncharacterized Tissue Antibodies  >97 publications with TH and Uncharacterized Tissue
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