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anti-HCK antibody :: Rabbit anti-Human Tyrosine-protein kinase HCK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1498941
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosine-protein kinase HCK, Polyclonal Antibody

 Also Known As   

Rabbit anti-human Tyrosine-protein kinase HCK polyclonal Antibody(HCK)

 Product Synonym Names    Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck; HCK
 Product Gene Name   

anti-HCK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142370
 3D Structure    ModBase 3D Structure for P08631
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Tyrosine-protein kinase HCK protein(1-220aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-72 / sc-11401
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HCK antibody

   Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
 Applications Tested/Suitable for anti-HCK antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HCK antibody    Recommended dilution: IHC:1:20-1:200
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 Immunohistochemistry (IHC) of anti-HCK antibody    Immunohistochemistry of paraffin-embedded human tonsil using MBS1498941 at dilution 1:100
anti-HCK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HCK antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS1498941 at dilution 1:100
anti-HCK antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
 NCBI GI #    287326139
 NCBI GeneID    3055
 NCBI Accession #    NP_001165600.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172129.1 [Other Products]
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 UniProt Primary Accession #    P08631 [Other Products]
 UniProt Secondary Accession #    Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; A8K1I1; B4DQB6; E1P5M2 [Other Products]
 UniProt Related Accession #    P08631 [Other Products]
 Molecular Weight    59,529 Da
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 NCBI Official Full Name    tyrosine-protein kinase HCK isoform b
 NCBI Official Synonym Full Names    HCK proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    HCK [Similar Products]
 NCBI Official Synonym Symbols   
JTK9; p59Hck; p61Hck
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase HCK
 UniProt Protein Name    Tyrosine-protein kinase HCK
 UniProt Synonym Protein Names   
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    HCK [Similar Products]
 UniProt Entry Name    HCK_HUMAN
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 NCBI Summary for HCK    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
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 UniProt Comments for HCK    Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: actin filament; caveola; cell projection; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; nucleus; transport vesicle

Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell adhesion; cell differentiation; cytokine and chemokine mediated signaling pathway; inflammatory response; innate immune response; innate immune response-activating signal transduction; integrin-mediated signaling pathway; leukocyte degranulation; leukocyte migration during immune response; lipopolysaccharide-mediated signaling pathway; mesoderm development; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape; regulation of defense response to virus by virus; regulation of inflammatory response; regulation of phagocytosis; regulation of transcription factor activity; respiratory burst after phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
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 Research Articles on HCK    1. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HCK antibodyPathways associated with anti-HCK antibody
 Reference Product  PubMed Publications
 BCR antibody  >39 publications with HCK and BCR
 CBL antibody  >17 publications with HCK and CBL
 STAT3 antibody  >11 publications with HCK and STAT3
 EGFR antibody  >9 publications with HCK and EGFR
 ABL1 antibody  >4 publications with HCK and ABL1
 BCAR1 antibody  >2 publications with HCK and BCAR1
 PXN antibody  >1 publications with HCK and PXN
 SOS1 antibody  >1 publications with HCK and SOS1
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
Diseases associated with anti-HCK antibodyOrgans/Tissues associated with anti-HCK antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >43 publications with HCK and Inflammation
 Necrosis Antibodies  >31 publications with HCK and Necrosis
 Carcinoma Antibodies  >24 publications with HCK and Carcinoma
 Lung Diseases Antibodies  >12 publications with HCK and Lung Diseases
 Kidney Diseases Antibodies  >9 publications with HCK and Kidney Diseases
 Brain Diseases Antibodies  >8 publications with HCK and Brain Diseases
 Vascular Diseases Antibodies  >8 publications with HCK and Vascular Diseases
 Cardiovascular Diseases Antibodies  >7 publications with HCK and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >6 publications with HCK and Breast Neoplasms
 Hyperplasia Antibodies  >5 publications with HCK and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >213 publications with HCK and Blood
 Lung Antibodies  >23 publications with HCK and Lung
 Kidney Antibodies  >17 publications with HCK and Kidney
 Spleen Antibodies  >15 publications with HCK and Spleen
 Eye Antibodies  >15 publications with HCK and Eye
 Brain Antibodies  >10 publications with HCK and Brain
 Prostate Antibodies  >10 publications with HCK and Prostate
 Testis Antibodies  >6 publications with HCK and Testis
 Ovary Antibodies  >5 publications with HCK and Ovary
 Embryonic Tissue Antibodies  >5 publications with HCK and Embryonic Tissue
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