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anti-YARS antibody :: Rabbit anti-Human Tyrosyl-tRNA synthetase, cytoplasmic Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000025
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosyl-tRNA synthetase, cytoplasmic (YARS), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Tyrosyl-tRNA synthetase, cytoplasmic polyclonal Antibody

 Product Synonym Names    YARS; Tyrosyl--tRNA ligase; TyrRS
 Product Gene Name   

anti-YARS antibody

[Similar Products]
 Product Synonym Gene Name    YARS [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603623
 3D Structure    ModBase 3D Structure for P54577
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Tyrosyl-tRNA synthetase, cytoplasmic protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26209 / sc-26207
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-YARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YARS antibody

   Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
 Product Categories/Family for anti-YARS antibody    Metabolism
 Applications Tested/Suitable for anti-YARS antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-YARS antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-YARS antibody    Western blot
All lanes: Tyrosyl-tRNA synthetase, cytoplasmic Antibody at 2ug/ml+293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

anti-YARS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-YARS antibody    Immunohistochemistry of paraffin-embeded human kidney using MBS7000025 at dilution of 1:50
anti-YARS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for YARS. It may not necessarily be applicable to this product.
 NCBI GI #    4507947
 NCBI GeneID    8565
 NCBI Accession #    NP_003671.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003680.3 [Other Products]
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 UniProt Primary Accession #    P54577 [Other Products]
 UniProt Secondary Accession #    O43276; Q53EN1; B3KWK4; D3DPQ4 [Other Products]
 UniProt Related Accession #    P54577 [Other Products]
 Molecular Weight    59,143 Da [Similar Products]
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 NCBI Official Full Name    tyrosine--tRNA ligase, cytoplasmic
 NCBI Official Synonym Full Names    tyrosyl-tRNA synthetase
 NCBI Official Symbol    YARS [Similar Products]
 NCBI Official Synonym Symbols   
YRS; YTS; TYRRS; CMTDIC
[Similar Products]
 NCBI Protein Information    tyrosine--tRNA ligase, cytoplasmic
 UniProt Protein Name    Tyrosine--tRNA ligase, cytoplasmic
 UniProt Synonym Protein Names   
Tyrosyl-tRNA synthetase; TyrRS
 Protein Family    Tyrosine--tRNA ligase
 UniProt Gene Name    YARS [Similar Products]
 UniProt Synonym Gene Names    TyrRS [Similar Products]
 UniProt Entry Name    SYYC_HUMAN
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 NCBI Summary for YARS    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YARS    YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family.

Protein type: EC 6.1.1.1; Ligase

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: cytoplasm; cytosol; extracellular space; nucleus

Molecular Function: ATP binding; interleukin-8 receptor binding; signal transducer activity; tRNA binding; tyrosine-tRNA ligase activity; valine-tRNA ligase activity

Biological Process: apoptosis; gene expression; signal transduction; tRNA aminoacylation for protein translation; tyrosyl-tRNA aminoacylation

Disease: Charcot-marie-tooth Disease, Dominant Intermediate C
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 Research Articles on YARS    1. the association of rare YARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YARS antibodyPathways associated with anti-YARS antibody
 Reference Product  PubMed Publications
 QARS antibody  >1 publications with YARS and QARS
 MARS antibody  >1 publications with YARS and MARS
 EPRS antibody  >1 publications with YARS and EPRS
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with anti-YARS antibodyOrgans/Tissues associated with anti-YARS antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with YARS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5 publications with YARS and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >4 publications with YARS and Nerve Degeneration
 Disease Models, Animal Antibodies  >4 publications with YARS and Disease Models, Animal
 Charcot-Marie-Tooth Disease, Dominant Intermediate C Antibodies  >4 publications with YARS and Charcot-Marie-Tooth Disease, Dominant Intermediate C
 Brain Diseases Antibodies  >2 publications with YARS and Brain Diseases
 Pain Antibodies  >2 publications with YARS and Pain
 Inflammation Antibodies  >2 publications with YARS and Inflammation
 Hypertension Antibodies  >1 publications with YARS and Hypertension
 Liver Neoplasms Antibodies  >1 publications with YARS and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >8 publications with YARS and Nerve
 Blood Antibodies  >5 publications with YARS and Blood
 Vascular Antibodies  >2 publications with YARS and Vascular
 Heart Antibodies  >2 publications with YARS and Heart
 Brain Antibodies  >2 publications with YARS and Brain
 Ovary Antibodies  >1 publications with YARS and Ovary
 Embryonic Tissue Antibodies  >1 publications with YARS and Embryonic Tissue
 Liver Antibodies  >1 publications with YARS and Liver
 Skin Antibodies  >1 publications with YARS and Skin
 Kidney Antibodies  >1 publications with YARS and Kidney
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