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anti-U2AF1 antibody :: Rabbit anti-Human U2AF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626020 anti-U2AF1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

U2AF1, Polyclonal Antibody

 Also Known As   

U2AF1, ID (S70) (Splicing Factor U2AF 35kD Subunit, U2 Auxiliary Factor 35kD Subunit, U2 snRNP Auxiliary Factor Small Subunit, U2AF35, U2AFBP)

 Product Synonym Names    Anti -U2AF1, ID (S70) (Splicing Factor U2AF 35kD Subunit, U2 Auxiliary Factor 35kD Subunit, U2 snRNP Auxiliary Factor Small Subunit, U2AF35, U2AFBP)
 Product Gene Name   

anti-U2AF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (44513066..44527716, complement). Location: 21q22.3
 OMIM    191317
 3D Structure    ModBase 3D Structure for Q701P4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human U2AF1.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the Center region of human U2AF1 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-U2AF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-U2AF1 antibody

   U2AF1 belongs to the splicing factor SR family. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers.
 Product Categories/Family for anti-U2AF1 antibody    Antibodies; Abs to Splicing Factors
 Applications Tested/Suitable for anti-U2AF1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-U2AF1 antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for U2AF1. It may not necessarily be applicable to this product.
 NCBI GI #    46911414
 NCBI GeneID    7307
 NCBI Accession #    CAF29556.1 [Other Products]
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 UniProt Primary Accession #    Q701P4 [Other Products]
 UniProt Secondary Accession #    Q701P4; Q71RF1 [Other Products]
 UniProt Related Accession #    Q01081 [Other Products]
 Molecular Weight    27,872 Da [Similar Products]
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 NCBI Official Full Name    U2 snRNP auxiliary factor small subunit
 NCBI Official Synonym Full Names    U2 small nuclear RNA auxiliary factor 1
 NCBI Official Symbol    U2AF1 [Similar Products]
 NCBI Official Synonym Symbols   
RN; FP793; U2AF35; U2AFBP; RNU2AF1
[Similar Products]
 NCBI Protein Information    splicing factor U2AF 35 kDa subunit; splicing factor U2AF 35kDa subunit; U2 small nuclear RNA auxillary factor 1; U2 snRNP auxiliary factor small subunit; U2(RNU2) small nuclear RNA auxiliary factor binding protein; U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
 UniProt Protein Name    Splicing factor U2AF 35 kDa subunit
 UniProt Synonym Protein Names   
U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit
 Protein Family    Splicing factor
 UniProt Gene Name    U2AF1 [Similar Products]
 UniProt Synonym Gene Names    U2AF35; U2AFBP [Similar Products]
 UniProt Entry Name    U2AF1_HUMAN
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 NCBI Summary for U2AF1    This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for U2AF1    U2AF1: Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; RNA-binding; RNA processing; RNA splicing

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; spliceosome; Cajal body; nuclear speck

Molecular Function: protein binding; RS domain binding; metal ion binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription
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 Research Articles on U2AF1    1. data suggest that SF3B1, U2AF1 and SRSF2 mutations occur not only in myeloid lineage tumors but also in lymphoid lineage tumors; data suggest that the splicing gene mutations play important roles in the pathogenesis of hematologic tumors, but rarely in solid tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-U2AF1 antibodyPathways associated with anti-U2AF1 antibody
 Reference Product  PubMed Publications
 SRSF2 antibody  >19 publications with U2AF1 and SRSF2
 U2AF2 antibody  >2 publications with U2AF1 and U2AF2
 SNRPD1 antibody  >1 publications with U2AF1 and SNRPD1
 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Shigellosis Pathway antibodies  Shigellosis Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
 Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway antibodies  Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway Diagram
Diseases associated with anti-U2AF1 antibodyOrgans/Tissues associated with anti-U2AF1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with U2AF1 and Neoplasms
 Myelodysplastic Syndromes Antibodies  >15 publications with U2AF1 and Myelodysplastic Syndromes
 Anemia Antibodies  >4 publications with U2AF1 and Anemia
 Cell Transformation, Neoplastic Antibodies  >3 publications with U2AF1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >2 publications with U2AF1 and Nervous System Diseases
 Lung Diseases Antibodies  >2 publications with U2AF1 and Lung Diseases
 Disease Models, Animal Antibodies  >2 publications with U2AF1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with U2AF1 and Neurobehavioral Manifestations
 Carcinoma, Hepatocellular Antibodies  >1 publications with U2AF1 and Carcinoma, Hepatocellular
 Skin Diseases Antibodies  >1 publications with U2AF1 and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >26 publications with U2AF1 and Nerve
 Blood Antibodies  >13 publications with U2AF1 and Blood
 Embryonic Tissue Antibodies  >13 publications with U2AF1 and Embryonic Tissue
 Brain Antibodies  >8 publications with U2AF1 and Brain
 Liver Antibodies  >5 publications with U2AF1 and Liver
 Lung Antibodies  >4 publications with U2AF1 and Lung
 Bone Marrow Antibodies  >4 publications with U2AF1 and Bone Marrow
 Muscle Antibodies  >4 publications with U2AF1 and Muscle
 Placenta Antibodies  >2 publications with U2AF1 and Placenta
 Kidney Antibodies  >2 publications with U2AF1 and Kidney
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