NP_001012496.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,121 Da
NCBI Official Full Name
splicing factor U2AF 65 kDa subunit isoform b
NCBI Official Synonym Full Names
U2 small nuclear RNA auxiliary factor 2
NCBI Official Synonym Symbols
NCBI Protein Information
splicing factor U2AF 65 kDa subunit
UniProt Protein Name
Splicing factor U2AF 65 kDa subunit
UniProt Synonym Protein Names
U2 auxiliary factor 65 kDa subunit; hU2AF(65); hU2AF65; U2 snRNP auxiliary factor large subunit
UniProt Synonym Gene Names
NCBI Summary for U2AF2
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
UniProt Comments for U2AF2
Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.
Research Articles on U2AF2
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Products associated with anti-U2AF2 antibody
Pathways associated with anti-U2AF2 antibody
Diseases associated with anti-U2AF2 antibody
Organs/Tissues associated with anti-U2AF2 antibody
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