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anti-U2AF2 antibody :: Rabbit U2AF2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9410392
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

U2AF2, Polyclonal Antibody

★Popular Item★
 Also Known As   

U2AF2 Antibody

 Product Synonym Names    U2AF65
 Product Gene Name   

anti-U2AF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191318
 3D Structure    ModBase 3D Structure for P26368
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of total U2AF2 protein.
 Purity/Purification    Antibodies were purified by affinity purification using immunogen.
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Recombinant protein of human U2AF2.
 Target Name    U2AF2
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-U2AF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-U2AF2 antibody

   U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
 Product Categories/Family for anti-U2AF2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-U2AF2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-U2AF2 antibody    Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200
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 Western Blot (WB) of anti-U2AF2 antibody    Western blot analysis of extracts of various cell lines, using U2AF2 antibody.
anti-U2AF2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-U2AF2 antibody    Immunofluorescence analysis of U2OS cell using U2AF2 antibody. Blue: DAPI for nuclear staining.
anti-U2AF2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for U2AF2. It may not necessarily be applicable to this product.
 NCBI GI #    60279268
 NCBI GeneID    11338
 NCBI Accession #    NP_001012496.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012478.1 [Other Products]
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 UniProt Primary Accession #    P26368 [Other Products]
 UniProt Secondary Accession #    Q96HC5 [Other Products]
 UniProt Related Accession #    P26368 [Other Products]
 Molecular Weight    53KD
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 NCBI Official Full Name    splicing factor U2AF 65 kDa subunit isoform b
 NCBI Official Synonym Full Names    U2 small nuclear RNA auxiliary factor 2
 NCBI Official Symbol    U2AF2 [Similar Products]
 NCBI Official Synonym Symbols   
U2AF65
[Similar Products]
 NCBI Protein Information    splicing factor U2AF 65 kDa subunit
 UniProt Protein Name    Splicing factor U2AF 65 kDa subunit
 UniProt Synonym Protein Names   
U2 auxiliary factor 65 kDa subunit; hU2AF(65); hU2AF65; U2 snRNP auxiliary factor large subunit
 Protein Family    Splicing factor
 UniProt Gene Name    U2AF2 [Similar Products]
 UniProt Synonym Gene Names    U2AF65; hU2AF(65); hU2AF65 [Similar Products]
 UniProt Entry Name    U2AF2_HUMAN
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 NCBI Summary for U2AF2    U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
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 UniProt Comments for U2AF2    U2AF2: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: nucleoplasm; spliceosome; nuclear speck

Molecular Function: protein binding; enzyme binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription; positive regulation of RNA splicing
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 Research Articles on U2AF2    1. The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-U2AF2 antibodyPathways associated with anti-U2AF2 antibody
 Reference Product  PubMed Publications
 U2AF1 antibody  >3 publications with U2AF2 and U2AF1
 SF3B1 antibody  >2 publications with U2AF2 and SF3B1
 SNRPA antibody  >1 publications with U2AF2 and SNRPA
 SF1 antibody  >1 publications with U2AF2 and SF1
 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
 Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway antibodies  Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway Diagram
 MRNA 3'-end Processing Pathway antibodies  MRNA 3'-end Processing Pathway Diagram
Diseases associated with anti-U2AF2 antibodyOrgans/Tissues associated with anti-U2AF2 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >2 publications with U2AF2 and Chromosome Aberrations
 Nervous System Diseases Antibodies  >1 publications with U2AF2 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with U2AF2 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with U2AF2 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with U2AF2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with U2AF2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with U2AF2 and Lung
 Skin Antibodies  >2 publications with U2AF2 and Skin
 Spleen Antibodies  >2 publications with U2AF2 and Spleen
 Brain Antibodies  >2 publications with U2AF2 and Brain
 Liver Antibodies  >2 publications with U2AF2 and Liver
 Ovary Antibodies  >2 publications with U2AF2 and Ovary
 Blood Antibodies  >2 publications with U2AF2 and Blood
 Kidney Antibodies  >1 publications with U2AF2 and Kidney
 Muscle Antibodies  >1 publications with U2AF2 and Muscle
 Lymph Antibodies  >1 publications with U2AF2 and Lymph
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