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anti-UBC13 antibody :: Rabbit anti-Mouse, Rat UBC13 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221854
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBC13, Polyclonal Antibody

 Also Known As   

RABBIT ANTI UBC13 (C-TERMINAL)

 Product Gene Name   

anti-UBC13 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603679
 3D Structure    ModBase 3D Structure for P61088
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide
 Histology Positive Control Tissue    Mouse thymus tissue
Buffer Solution
 Antiserum Preparation    Antisera to human UBC13 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-UBC13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-UBC13 antibody

   Rabbit anti Human UBC13 antibody recognizes the C-terminal (CT) region of Ubiquitin-conjugating enzyme E2N (UBC13), also known as Bendless-like ubiquitin-conjugating enzyme, Ubiquitin carrier protein N or Ubiquitin-protein ligase N. UBC13 is a ~16kDa enzyme which is an important component of the TLR (Toll-like receptor) and IL-1R signalling pathway. UBC13 is a DNA-damage inducible protein which forms part of an enzyme complex, with UEV1A, that indirectly activates TAK1 via the ubiquitination of TRAF-6. Ubiquitin modification of proteins is important for error-free DNA repair and for targeting of short-lived or abnormal proteins for degradation (Martein et al. 2009).
 Applications Tested/Suitable for anti-UBC13 antibody   

Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-UBC13 antibody    Western Blot: Rabbit anti human UBC13 antibody detects a band of ~16kDa in human small intestine cell lystates.
Immunohistology - Paraffin: Maximum Dilution: 2ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5ug/ml; Maximum Dilution: 1ug/ml
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 Testing Data #1 of anti-UBC13 antibody    Western blot analysis of human small intestine lysate probed with Rabbit anti Human Ubc13 (MBS221854) at 0.5(A), 1(B) and 2(C) ug/ml
anti-UBC13 antibody Testing Data #1 image
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 Testing Data #2 of anti-UBC13 antibody    Immunohistochemical staining of mouse thymus with Rabbit anti Mouse Ubc13 (MBS221854)
anti-UBC13 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for UBC13. It may not necessarily be applicable to this product.
 NCBI GI #    4507793
 NCBI GeneID    7334
 NCBI Accession #    NP_003339.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003348.3 [Other Products]
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 UniProt Primary Accession #    P61088 [Other Products]
 UniProt Secondary Accession #    Q16781; Q53Y81 [Other Products]
 UniProt Related Accession #    P61088 [Other Products]
 Molecular Weight    17,138 Da
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 N
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2N
 NCBI Official Symbol    UBE2N [Similar Products]
 NCBI Official Synonym Symbols   
UBC13; UbcH13; HEL-S-71; UbcH-ben; UBCHBEN; UBC13
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 N; bendless-like ubiquitin conjugating enzyme; bendless-like ubiquitin-conjugating enzyme; epididymis secretory protein Li 71; ubiquitin carrier protein N; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-protein ligase N; yeast UBC13 homolog
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 N
 UniProt Synonym Protein Names   
Bendless-like ubiquitin-conjugating enzyme; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N
 UniProt Gene Name    UBE2N [Similar Products]
 UniProt Synonym Gene Names    BLU [Similar Products]
 UniProt Entry Name    UBE2N_HUMAN
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 NCBI Summary for UBC13    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UBC13    UBE2N: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Heterodimer with UBE2V2. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with RNF8 and RNF168. Interacts with RNF11. Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair. Interacts with ARIH2 (via RING-type 2). Belongs to the ubiquitin-conjugating enzyme family.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; DNA repair, damage; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: protein complex; cytoplasm; cytosol; nucleus; ubiquitin ligase complex; UBC13-MMS2 complex

Molecular Function: ubiquitin binding; protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; regulation of histone ubiquitination; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of DNA repair; postreplication repair; positive regulation of histone modification; cytokine and chemokine mediated signaling pathway; DNA double-strand break processing; protein modification process; protein ubiquitination; proteolysis; T cell receptor signaling pathway; double-strand break repair via homologous recombination; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of DNA repair; toll-like receptor 5 signaling pathway; positive regulation of ubiquitin-protein ligase activity; histone ubiquitination; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
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 Research Articles on UBC13    1. UBE2N inhibition induces neuroblastoma apoptotic cell death via activation of p53 and JNK pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UBC13 antibodyPathways associated with anti-UBC13 antibody
 Reference Product  PubMed Publications
 RNF8 antibody  >17 publications with UBC13 and RNF8
 UBE2V1 antibody  >17 publications with UBC13 and UBE2V1
 TRAF6 antibody  >15 publications with UBC13 and TRAF6
 UBE2V2 antibody  >11 publications with UBC13 and UBE2V2
 OTUB1 antibody  >6 publications with UBC13 and OTUB1
 UBC antibody  >5 publications with UBC13 and UBC
 UEV1 antibody  >3 publications with UBC13 and UEV1
 STUB1 antibody  >2 publications with UBC13 and STUB1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
Diseases associated with anti-UBC13 antibodyOrgans/Tissues associated with anti-UBC13 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with UBC13 and Necrosis
 Inflammation Antibodies  >5 publications with UBC13 and Inflammation
 Lung Diseases Antibodies  >3 publications with UBC13 and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with UBC13 and Lung Neoplasms
 Immune System Diseases Antibodies  >2 publications with UBC13 and Immune System Diseases
 Gastrointestinal Diseases Antibodies  >2 publications with UBC13 and Gastrointestinal Diseases
 Brain Diseases Antibodies  >2 publications with UBC13 and Brain Diseases
 Precancerous Conditions Antibodies  >1 publications with UBC13 and Precancerous Conditions
 Fibrosis Antibodies  >1 publications with UBC13 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with UBC13 and Blood
 Lung Antibodies  >3 publications with UBC13 and Lung
 Brain Antibodies  >3 publications with UBC13 and Brain
 Bone Antibodies  >2 publications with UBC13 and Bone
 Kidney Antibodies  >2 publications with UBC13 and Kidney
 Skin Antibodies  >2 publications with UBC13 and Skin
 Testis Antibodies  >2 publications with UBC13 and Testis
 Liver Antibodies  >1 publications with UBC13 and Liver
 Intestine Antibodies  >1 publications with UBC13 and Intestine
 Embryonic Tissue Antibodies  >1 publications with UBC13 and Embryonic Tissue
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