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anti-UBE2D1 antibody :: Rabbit UBE2D1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127916
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBE2D1, Polyclonal Antibody

 Also Known As   

UBE2D1 Polyclonal Antibody

 Product Synonym Names    SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1
 Product Gene Name   

anti-UBE2D1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602961
 3D Structure    ModBase 3D Structure for P51668
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human UBE2D1
 Calculated Molecular Weight    17kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-UBE2D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-UBE2D1 antibody

   The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-UBE2D1 antibody    Polyclonal
 Applications Tested/Suitable for anti-UBE2D1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-UBE2D1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-UBE2D1 antibody    Western blot analysis of extracts of various cell lines, using UBE2D1 antibody.
anti-UBE2D1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UBE2D1. It may not necessarily be applicable to this product.
 NCBI GI #    1717848
 NCBI GeneID    7321
 NCBI Accession #    P51668.1 [Other Products]
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 UniProt Primary Accession #    P51668 [Other Products]
 UniProt Secondary Accession #    A6NLF6; A8K786 [Other Products]
 UniProt Related Accession #    P51668 [Other Products]
 Molecular Weight    147
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 NCBI Official Full Name    Ubiquitin-conjugating enzyme E2 D1
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2D 1
 NCBI Official Symbol    UBE2D1 [Similar Products]
 NCBI Official Synonym Symbols   
SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 D1; UBC4/5 homolog; stimulator of Fe transport; ubiquitin-protein ligase D1; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 D1
 UniProt Synonym Protein Names   
Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2D1 [Similar Products]
 UniProt Synonym Gene Names    SFT; UBC5A; UBCH5; UBCH5A; SFT [Similar Products]
 UniProt Entry Name    UB2D1_HUMAN
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 NCBI Summary for UBE2D1    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for UBE2D1    UBE2D1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; BMP signaling pathway; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; transforming growth factor beta receptor signaling pathway; mitotic cell cycle spindle assembly checkpoint; toll-like receptor signaling pathway; innate immune response; gene expression; mitotic cell cycle; toll-like receptor 4 signaling pathway
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 Research Articles on UBE2D1    1. The SMURF2:UBCH5 complex is critical in maintaining KRAS protein stability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UBE2D1 antibodyPathways associated with anti-UBE2D1 antibody
 Reference Product  PubMed Publications
 STUB1 antibody  >5 publications with UBE2D1 and STUB1
 MDM2 antibody  >2 publications with UBE2D1 and MDM2
 BARD1 antibody  >2 publications with UBE2D1 and BARD1
 BRCA1 antibody  >2 publications with UBE2D1 and BRCA1
 BIRC2 antibody  >1 publications with UBE2D1 and BIRC2
 XIAP antibody  >1 publications with UBE2D1 and XIAP
 MYLIP antibody  >1 publications with UBE2D1 and MYLIP
 UBC antibody  >1 publications with UBE2D1 and UBC
 Products by Pathway  Pathway Diagram
 APC-Cdc20 Mediated Degradation Of Nek2A Pathway antibodies  APC-Cdc20 Mediated Degradation Of Nek2A Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
Diseases associated with anti-UBE2D1 antibodyOrgans/Tissues associated with anti-UBE2D1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >3 publications with UBE2D1 and Anemia
 Fibrosis Antibodies  >2 publications with UBE2D1 and Fibrosis
 Inflammation Antibodies  >2 publications with UBE2D1 and Inflammation
 Necrosis Antibodies  >2 publications with UBE2D1 and Necrosis
 Breast Neoplasms Antibodies  >1 publications with UBE2D1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >1 publications with UBE2D1 and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with UBE2D1 and Nervous System Diseases
 Anoxia Antibodies  >1 publications with UBE2D1 and Anoxia
 Lung Neoplasms Antibodies  >1 publications with UBE2D1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with UBE2D1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with UBE2D1 and Liver
 Intestine Antibodies  >7 publications with UBE2D1 and Intestine
 Blood Antibodies  >5 publications with UBE2D1 and Blood
 Kidney Antibodies  >4 publications with UBE2D1 and Kidney
 Lung Antibodies  >3 publications with UBE2D1 and Lung
 Brain Antibodies  >3 publications with UBE2D1 and Brain
 Muscle Antibodies  >2 publications with UBE2D1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with UBE2D1 and Embryonic Tissue
 Placenta Antibodies  >1 publications with UBE2D1 and Placenta
 Heart Antibodies  >1 publications with UBE2D1 and Heart
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