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anti-UBE2D2 antibody :: Rabbit UBE2D2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203652
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBE2D2, Polyclonal Antibody

★Popular Item★
 Also Known As   

UBE2D2 Antibody

 Product Synonym Names    Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1; UBE2D2; PUBC1; UBC4; UBC5B; UBCH4; UBCH5B
 Product Gene Name   

anti-UBE2D2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    81-140
 OMIM    602962
 3D Structure    ModBase 3D Structure for P62837
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
 Concentration    1mg/ml (lot specific)
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 Antigen Type    synthetic peptide
 Antigen Source    KLH conjugated synthetic peptide derived from human UBE2D2
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 Preparation and Storage    Store at -20 degree C.Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-UBE2D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-UBE2D2 antibody

   Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
 Product Categories/Family for anti-UBE2D2 antibody    Cell Biology
 Applications Tested/Suitable for anti-UBE2D2 antibody   

Western Blot (WB)

 Application Notes for anti-UBE2D2 antibody    WB~~ 1:1000
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 Western Blot (WB) of anti-UBE2D2 antibody    All lanes : Anti-UBE2D2 Antibody at 1:1000 dilution
Lane 1: Hela whole cell lysates
Lane 2: HepG2 whole cell lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 17 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-UBE2D2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UBE2D2. It may not necessarily be applicable to this product.
 NCBI GI #    4507775
 NCBI GeneID    7322
 NCBI Accession #    NP_003330.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003339.2 [Other Products]
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 UniProt Primary Accession #    P62837 [Other Products]
 UniProt Secondary Accession #    P51669; Q3MN78; Q96RP6; D3DQC9 [Other Products]
 UniProt Related Accession #    P62837 [Other Products]
 Molecular Weight    17 KDa
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 D2 isoform 1
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2D 2
 NCBI Official Symbol    UBE2D2 [Similar Products]
 NCBI Official Synonym Symbols   
UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 D2
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 D2
 UniProt Synonym Protein Names   
Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2D2 [Similar Products]
 UniProt Synonym Gene Names    PUBC1; UBC4; UBC5B; UBCH4; UBCH5B [Similar Products]
 UniProt Entry Name    UB2D2_HUMAN
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 NCBI Summary for UBE2D2    Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for UBE2D2    UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; protein complex; cytosol; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; protein polyubiquitination; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein modification process; innate immune response; protein ubiquitination; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
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Product References and Citations for anti-UBE2D2 antibody

   Jensen J.P.,et al.J. Biol. Chem. 270:30408-30414(1995).
Rolfe M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3264-3268(1995).
Guinn B.-A.,et al.Biochem. Biophys. Res. Commun. 335:1293-1304(2005).
Yin Y.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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 Research Articles on UBE2D2    1. Presented is the structure of the human dimeric RING domain from BIRC7 in complex with the E2 UbcH5B covalently linked to Ub.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UBE2D2 antibodyDiseases associated with anti-UBE2D2 antibody
 Reference Product  PubMed Publications
 MDM2 antibody  >4 publications with UBE2D2 and MDM2
 CBL antibody  >3 publications with UBE2D2 and CBL
 NEDD4 antibody  >2 publications with UBE2D2 and NEDD4
 STUB1 antibody  >2 publications with UBE2D2 and STUB1
 CNOT4 antibody  >2 publications with UBE2D2 and CNOT4
 BIRC3 antibody  >1 publications with UBE2D2 and BIRC3
 RBX1 antibody  >1 publications with UBE2D2 and RBX1
 UBC antibody  >1 publications with UBE2D2 and UBC
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with UBE2D2 and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with UBE2D2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with UBE2D2 and Disease Models, Animal
 Immune System Diseases Antibodies  >2 publications with UBE2D2 and Immune System Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with UBE2D2 and Neurodegenerative Diseases
 Cardiovascular Diseases Antibodies  >2 publications with UBE2D2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >1 publications with UBE2D2 and Liver Diseases
 Prenatal Injuries Antibodies  >1 publications with UBE2D2 and Prenatal Injuries
 Neurobehavioral Manifestations Antibodies  >1 publications with UBE2D2 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with UBE2D2 and Learning Disorders
Organs/Tissues associated with anti-UBE2D2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with UBE2D2 and Brain
 Blood Antibodies  >4 publications with UBE2D2 and Blood
 Placenta Antibodies  >3 publications with UBE2D2 and Placenta
 Kidney Antibodies  >2 publications with UBE2D2 and Kidney
 Testis Antibodies  >2 publications with UBE2D2 and Testis
 Liver Antibodies  >2 publications with UBE2D2 and Liver
 Intestine Antibodies  >1 publications with UBE2D2 and Intestine
 Thymus Antibodies  >1 publications with UBE2D2 and Thymus
 Lung Antibodies  >1 publications with UBE2D2 and Lung
 Embryonic Tissue Antibodies  >1 publications with UBE2D2 and Embryonic Tissue
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