NP_003331.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 17 kDa Predicted: 17 kDa
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 D3 isoform 1
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 D3
NCBI Protein Information
ubiquitin-conjugating enzyme E2 D3
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 D3
UniProt Synonym Protein Names
(E3-independent) E2 ubiquitin-conjugating enzyme D3 (EC:2.3.2.241 PublicationManual assertion based on experiment iniRef.15"E3-independent monoubiquitination of ubiquitin-binding proteins."Hoeller D., Hecker C.M., Wagner S., Rogov V., Doetsch V., Dikic I.Mol. Cell 26:891-898(2007) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY AS E3-INDEPENDENT E2 UBIQUITIN-CONJUGATING ENZYME.
UniProt Synonym Gene Names
NCBI Summary for UBE2D3
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]
UniProt Comments for UBE2D3
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
Research Articles on UBE2D3
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Products associated with anti-UBE2D3 antibody
Pathways associated with anti-UBE2D3 antibody
Diseases associated with anti-UBE2D3 antibody
Organs/Tissues associated with anti-UBE2D3 antibody
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