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anti-UBE2L3 antibody :: Goat UBE2L3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420751
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBE2L3, Polyclonal Antibody

 Also Known As   

Goat anti-UBE2L3 Antibody

 Product Synonym Names    UBE2L3; ubiquitin-conjugating enzyme E2L 3; UBCH7; E2-F1; L-UBC; UbcM4; ubiquitin carrier protein; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase; UBE2L3 antibody; ubiquitin-conjugating enzyme E2L 3 antibody; UBCH7 antibody; E2-F1 antibody; L-UBC antibody; UbcM4 antibody; ubiquitin carrier protein antibody; ubiquitin-conjugating enzyme UBCH7 antibody; ubiquitin-protein ligase antibody
 Product Gene Name   

anti-UBE2L3 antibody

[Similar Products]
 Antibody/Peptide Pairs    UBE2L3 peptide (MBS425349) is used for blocking the activity of UBE2L3 antibody (MBS420751)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EFTKKYGEKR PVD
 OMIM    603721
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat, Pig; Expected from sequence similarity: Human, Mouse, Rat, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EFTKKYGEKRPVD, from the C Terminus of the protein sequence according to NP_003338.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-UBE2L3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UBE2L3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-UBE2L3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 18kDa band observed in lysates of cell lines HeLa HEK293, HepG2 and Jurkat and also in lysates of Human, Mouse and Rat Heart, Skeletal Muscle and Testis and of Pig Heart (calculated MW of 17.9kDa according to Human NP_003338.1 and Mouse NP_033482.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-UBE2L3 antibody    Staining (0.5ug/ml) of Hela lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-UBE2L3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-UBE2L3 antibody    (0. 01ug/ml) staining of Human (A), Mouse (B), Rat (C) and Pig (D) Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-UBE2L3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-UBE2L3 antibody    (0. 03ug/ml) staining of Human (A), Mouse (B) and Rat (C) Skeletal Muscle lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-UBE2L3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-UBE2L3 antibody    (0. 01ug/ml) staining of HEK293 (A), HepG2 (B) and Jurkat (C) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-UBE2L3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UBE2L3. It may not necessarily be applicable to this product.
 NCBI GI #    4507789
 NCBI GeneID    7332
 NCBI Accession #    NP_003338.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003347.3 [Other Products]
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 UniProt Secondary Accession #    P51966; P70653; Q9HAV1; B2R4A7; B4DDG1; B4DSZ4; E7EWS7 [Other Products]
 UniProt Related Accession #    P68036 [Other Products]
 Molecular Weight    24,004 Da
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 L3 isoform 1
 NCBI Official Synonym Full Names    ubiquitin conjugating enzyme E2 L3
 NCBI Official Symbol    UBE2L3 [Similar Products]
 NCBI Official Synonym Symbols   
E2-F1; L-UBC; UBCH7; UbcM4
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 L3
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 L3
 UniProt Synonym Protein Names   
E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2L3 [Similar Products]
 UniProt Synonym Gene Names    UBCE7; UBCH7 [Similar Products]
 UniProt Entry Name    UB2L3_HUMAN
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 NCBI Summary for UBE2L3    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for UBE2L3    UBE2L3: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1. Ubiquitous, with highest expression in testis. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Ligase; Nuclear receptor co-regulator; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function: ATP binding; enzyme binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: cell proliferation; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; protein modification process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
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 Research Articles on UBE2L3    1. together with UBE2N and UBE2D2, synergistically contribute to Parkin-mediated mitophagy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UBE2L3 antibodyPathways associated with anti-UBE2L3 antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >11 publications with UBE2L3 and PARK2
 CBL antibody  >10 publications with UBE2L3 and CBL
 UBC antibody  >8 publications with UBE2L3 and UBC
 ARIH1 antibody  >6 publications with UBE2L3 and ARIH1
 UBE3A antibody  >3 publications with UBE2L3 and UBE3A
 NEDD4 antibody  >2 publications with UBE2L3 and NEDD4
 ARIH2 antibody  >2 publications with UBE2L3 and ARIH2
 ITCH antibody  >1 publications with UBE2L3 and ITCH
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with anti-UBE2L3 antibodyOrgans/Tissues associated with anti-UBE2L3 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >14 publications with UBE2L3 and Immune System Diseases
 Death Antibodies  >11 publications with UBE2L3 and Death
 Nervous System Diseases Antibodies  >11 publications with UBE2L3 and Nervous System Diseases
 Liver Diseases Antibodies  >4 publications with UBE2L3 and Liver Diseases
 Inflammation Antibodies  >4 publications with UBE2L3 and Inflammation
 Necrosis Antibodies  >4 publications with UBE2L3 and Necrosis
 Lung Diseases Antibodies  >3 publications with UBE2L3 and Lung Diseases
 Fibrosis Antibodies  >2 publications with UBE2L3 and Fibrosis
 Congenital Abnormalities Antibodies  >2 publications with UBE2L3 and Congenital Abnormalities
 Hepatitis B, Chronic Antibodies  >2 publications with UBE2L3 and Hepatitis B, Chronic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with UBE2L3 and Blood
 Brain Antibodies  >10 publications with UBE2L3 and Brain
 Liver Antibodies  >6 publications with UBE2L3 and Liver
 Skin Antibodies  >4 publications with UBE2L3 and Skin
 Lung Antibodies  >4 publications with UBE2L3 and Lung
 Nerve Antibodies  >4 publications with UBE2L3 and Nerve
 Muscle Antibodies  >4 publications with UBE2L3 and Muscle
 Prostate Antibodies  >2 publications with UBE2L3 and Prostate
 Heart Antibodies  >2 publications with UBE2L3 and Heart
 Pancreas Antibodies  >1 publications with UBE2L3 and Pancreas
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