NP_001070151.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 90 kD Predicted: 90 kDa
NCBI Official Full Name
nucleolar transcription factor 1 isoform b
NCBI Official Synonym Full Names
upstream binding transcription factor
NCBI Official Synonym Symbols
UBF; UBF1; UBF2; UBF-1; CONDBA; NOR-90 [Similar Products]
NCBI Protein Information
nucleolar transcription factor 1
UniProt Protein Name
Nucleolar transcription factor 1
UniProt Synonym Protein Names
Autoantigen NOR-90; Upstream-binding factor 1; UBF-1
UniProt Synonym Gene Names
NCBI Summary for UBF1
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
UniProt Comments for UBF1
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Research Articles on UBF1
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Products associated with anti-UBF1 antibody
Pathways associated with anti-UBF1 antibody
Diseases associated with anti-UBF1 antibody
Organs/Tissues associated with anti-UBF1 antibody
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