NP_777576.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 36 kD Predicted: 201 kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase UBR1
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 1
NCBI Official Synonym Symbols
NCBI Protein Information
E3 ubiquitin-protein ligase UBR1
UniProt Protein Name
E3 ubiquitin-protein ligase UBR1
UniProt Synonym Protein Names
N-recognin-1; RING-type E3 ubiquitin transferase UBR1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
NCBI Summary for UBR1
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for UBR1
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Research Articles on UBR1
Precautions
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Products associated with anti-UBR1 antibody
Pathways associated with anti-UBR1 antibody
Diseases associated with anti-UBR1 antibody
Organs/Tissues associated with anti-UBR1 antibody
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