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anti-UCHL5 antibody :: Rabbit anti-Human, Mouse UCH37 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626566 anti-UCHL5 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCH37 (UCHL5), Polyclonal Antibody

 Also Known As   

UCH37, NT (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L5, Ubiquitin Thiolesterase L5, Ubiquitin C-terminal Hydrolase UCH37, CGI-70, AD-019, UCHL5)

 Product Synonym Names    Anti -UCH37, NT (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L5, Ubiquitin Thiolesterase L5, Ubiquitin C-terminal Hydrolase UCH37, CGI-70, AD-019, UCHL5)
 Product Gene Name   

anti-UCHL5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (192981496..193029237, complement). Location: 1q32
 OMIM    610667
 3D Structure    ModBase 3D Structure for Q9Y5K5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes human UCHL5. Species Crossreactivity: mouse.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the N-terminal region of human UCHL5 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-UCHL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-UCHL5 antibody

   Covalent attachment of the C-terminus of ubiquitin to cellular proteins plays a role in a variety of cellular processes. Ubiquitin C-terminal hydrolysis is catalyzed by deubiquitinating (DUB) enzymes and is necessary for several functions, including liberation of monomeric ubiquitin from the precursors encoded by ubiquitin genes and recycling of ubiquitin monomers. There are 2 distinct families of DUBs, ubiquitin-specific proteases (UBPs) and ubiquitin C-terminal hydrolases (UCHs). Mayer and Wilkinson (1989) identified 4 distinct UCH activities from bovine thymus. All 4 were thiol proteases and had high-affinity binding sites for ubiquitin. Wilkinson et al. (1989) purified the predominant isozyme, UCHL3, and raised antibodies against it. By screening a human B-cell expression library with the antibodies, the authors isolated cDNAs encoding human UCHL3. Sequence comparisons revealed that the sequence of the predicted 230aa human UCHL3 protein is 54% identical to that of UCHL1.
 Product Categories/Family for anti-UCHL5 antibody    Antibodies; Abs to Ubiquitin
 Applications Tested/Suitable for anti-UCHL5 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-UCHL5 antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for UCHL5. It may not necessarily be applicable to this product.
 NCBI GI #    312922359
 NCBI GeneID    51377
 NCBI Accession #    NP_001186190.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199261.1 [Other Products]
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 UniProt Primary Accession #    Q9Y5K5 [Other Products]
 UniProt Secondary Accession #    Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2 [Other Products]
 UniProt Related Accession #    Q9Y5K5 [Other Products]
 Molecular Weight    37,607 Da [Similar Products]
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
 NCBI Official Synonym Full Names    ubiquitin carboxyl-terminal hydrolase L5
 NCBI Official Symbol    UCHL5 [Similar Products]
 NCBI Official Synonym Symbols   
UCH37; CGI-70; INO80R; UCH-L5
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L5; INO80 complex subunit R; ubiquitin thioesterase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L5
 UniProt Synonym Protein Names   
Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    UCHL5 [Similar Products]
 UniProt Synonym Gene Names    UCH37; UCH-L5 [Similar Products]
 UniProt Entry Name    UCHL5_HUMAN
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 UniProt Comments for UCHL5    UCHL5: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: proteasome complex; cytosol; nucleus

Molecular Function: omega peptidase activity; protein binding; endopeptidase inhibitor activity; ubiquitin-specific protease activity

Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; midbrain development; negative regulation of transforming growth factor beta receptor signaling pathway; forebrain morphogenesis; DNA repair; lateral ventricle development; DNA recombination
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 Research Articles on UCHL5    1. UCH37 over-expression is associated with hepatocellular carcinoma recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UCHL5 antibodyPathways associated with anti-UCHL5 antibody
 Reference Product  PubMed Publications
 ADRM1 antibody  >8 publications with UCHL5 and ADRM1
 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram
Diseases associated with anti-UCHL5 antibodyOrgans/Tissues associated with anti-UCHL5 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with UCHL5 and Neoplasms
 Adenocarcinoma Antibodies  >3 publications with UCHL5 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with UCHL5 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >2 publications with UCHL5 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >2 publications with UCHL5 and Carcinoma, Squamous Cell
 Liver Neoplasms Antibodies  >2 publications with UCHL5 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with UCHL5 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with UCHL5 and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >1 publications with UCHL5 and Gastrointestinal Diseases
 Esophageal Neoplasms Antibodies  >1 publications with UCHL5 and Esophageal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with UCHL5 and Liver
 Kidney Antibodies  >2 publications with UCHL5 and Kidney
 Cervix Antibodies  >1 publications with UCHL5 and Cervix
 Blood Antibodies  >1 publications with UCHL5 and Blood
 Lymph Node Antibodies  >1 publications with UCHL5 and Lymph Node
 Uterus Antibodies  >1 publications with UCHL5 and Uterus
 Lung Antibodies  >1 publications with UCHL5 and Lung
 Skin Antibodies  >1 publications with UCHL5 and Skin
 Spleen Antibodies  >1 publications with UCHL5 and Spleen
 Lymph Antibodies  >1 publications with UCHL5 and Lymph
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