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anti-UCHL1 antibody :: Goat UCHL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422428
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCHL1, Polyclonal Antibody

 Also Known As   

Goat anti-UCHL1 (aa 211-221) Antibody

 Product Synonym Names    Goat Anti-UCHL1 (aa 58-68) Antibody; UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); PARK5; PGP9.5; PGP95; Uch-L1; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase; ubiquitin carboxyl-terminal esterase L1; neuron cytoplasmic protein 9.5 antibody; PARK5 antibody; PGP9.5 antibody; PGP95 antibody; ubiquitin carboxyl-terminal esterase L1 antibody; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) antibody; ubiquitin C-terminal hydrolase antibody; Uch-L1 antibody; UCHL1 antibody; UCHL1 (aa 211-221)
 Product Gene Name   

anti-UCHL1 antibody

[Similar Products]
 Antibody/Peptide Pairs    UCHL1 peptide (MBS427374) is used for blocking the activity of UCHL1 antibody (MBS422428)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EVRFSAVALC K
 OMIM    191342
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence EVRFSAVALCK, from the C Terminus of the protein sequence according to NP_004172.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-UCHL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UCHL1 antibody   

Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-UCHL1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Approx 26kDa band observed in Human Brain (Hippocampus) and Mouse and Rat Brain lysates (calculated MW of 24.8kDa according to Human NP_004172.2, Mouse NP_035800.2 and Rat NP_058933.2). Recommended concentration: 0.01-0.03ug/ml.
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 Western Blot (WB) of anti-UCHL1 antibody    (0. 01ug/ml) staining of Mouse (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-UCHL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UCHL1. It may not necessarily be applicable to this product.
 NCBI GI #    21361091
 NCBI GeneID    7345
 NCBI Accession #    NP_004172.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004181.4 [Other Products]
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 UniProt Secondary Accession #    Q4W5K6; Q71UM0 [Other Products]
 UniProt Related Accession #    P09936 [Other Products]
 Molecular Weight    24,824 Da
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L1
 NCBI Official Synonym Full Names    ubiquitin C-terminal hydrolase L1
 NCBI Official Symbol    UCHL1 [Similar Products]
 NCBI Official Synonym Symbols   
NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Synonym Protein Names   
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    UCHL1 [Similar Products]
 UniProt Synonym Gene Names    UCH-L1; PGP9.5 [Similar Products]
 UniProt Entry Name    UCHL1_HUMAN
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 NCBI Summary for UCHL1    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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 UniProt Comments for UCHL1    UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.

Protein type: Protease; Ubiquitin conjugating system; Ligase; EC 3.4.19.12; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: cell soma; cytoplasm; cytosol; endoplasmic reticulum membrane; myelin sheath; nucleoplasm; plasma membrane

Molecular Function: alpha-2A adrenergic receptor binding; cysteine-type endopeptidase activity; ligase activity; omega peptidase activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity

Biological Process: adult walking behavior; axon target recognition; axon transport of mitochondrion; cell proliferation; eating behavior; muscle fiber development; negative regulation of MAP kinase activity; neuromuscular process; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of macroautophagy; sensory perception of pain

Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
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 Research Articles on UCHL1    1. High Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UCHL1 antibodyPathways associated with anti-UCHL1 antibody
 Reference Product  PubMed Publications
 SNCA antibody  >30 publications with UCHL1 and SNCA
 CDKN2A antibody  >4 publications with UCHL1 and CDKN2A
 TP53 antibody  >4 publications with UCHL1 and TP53
 HSP90AA1 antibody  >2 publications with UCHL1 and HSP90AA1
 COPS5 antibody  >1 publications with UCHL1 and COPS5
 HSPA8 antibody  >1 publications with UCHL1 and HSPA8
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
Diseases associated with anti-UCHL1 antibodyOrgans/Tissues associated with anti-UCHL1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >241 publications with UCHL1 and Nervous System Diseases
 Brain Diseases Antibodies  >172 publications with UCHL1 and Brain Diseases
 Movement Disorders Antibodies  >104 publications with UCHL1 and Movement Disorders
 Inflammation Antibodies  >48 publications with UCHL1 and Inflammation
 Disease Models, Animal Antibodies  >43 publications with UCHL1 and Disease Models, Animal
 Peripheral Nervous System Diseases Antibodies  >36 publications with UCHL1 and Peripheral Nervous System Diseases
 Cardiovascular Diseases Antibodies  >35 publications with UCHL1 and Cardiovascular Diseases
 Necrosis Antibodies  >25 publications with UCHL1 and Necrosis
 Nerve Degeneration Antibodies  >22 publications with UCHL1 and Nerve Degeneration
 Brain Injuries Antibodies  >18 publications with UCHL1 and Brain Injuries
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >218 publications with UCHL1 and Nerve
 Brain Antibodies  >141 publications with UCHL1 and Brain
 Skin Antibodies  >102 publications with UCHL1 and Skin
 Lymph Antibodies  >65 publications with UCHL1 and Lymph
 Muscle Antibodies  >64 publications with UCHL1 and Muscle
 Bone Antibodies  >64 publications with UCHL1 and Bone
 Lymph Node Antibodies  >63 publications with UCHL1 and Lymph Node
 Vascular Antibodies  >60 publications with UCHL1 and Vascular
 Lung Antibodies  >43 publications with UCHL1 and Lung
 Bone Marrow Antibodies  >37 publications with UCHL1 and Bone Marrow
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