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anti-UCHL3 antibody :: Rabbit UCHL3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240148
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCHL3, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human UCHL3

 Product Synonym Names    Anti-UCHL3 Antibody (Internal) IHC-plus; UCHL3; Ubiquitin thiolesterase; Ubiquitin thioesterase L3; UCH-L3; Human UCHL3
 Product Gene Name   

anti-UCHL3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603090
 3D Structure    ModBase 3D Structure for P15374
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Chicken, Dog, Gorilla, Human, Mouse, Rat
Predicted Reactivity: Orangutan, Monkey, Bovine, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
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 Specificity    Human UCHL3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 18 amino acid peptide from internal region of human UCHL3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Dog, Elephant, Opossum, Turkey, Chicken, Lizard (100%).
 Immunogen Type    Synthetic peptide
 Immunogen    UCHL3 antibody was raised against synthetic 18 amino acid peptide from internal region of human UCHL3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Dog, Elephant, Opossum, Turkey, Chicken, Lizard (100%); Orangutan, Monkey, Bovine, Horse, Rabbit, Pig, Salmon (94%); Pufferfish, Zebrafish, Stickleback, Water flea (89%); Xenopus (83%).
 Antigen Modification    Internal
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-UCHL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-UCHL3 antibody    Family: Protease
Subfamily: Cysteine C12
 Applications Tested/Suitable for anti-UCHL3 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-UCHL3 antibody    IHC-P (5 - 10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-UCHL3 antibody    Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-UCHL3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for UCHL3. It may not necessarily be applicable to this product.
 NCBI GI #    5174741
 NCBI GeneID    7347
 NCBI Accession #    NP_005993.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006002.4 [Other Products]
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 UniProt Primary Accession #    P15374 [Other Products]
 UniProt Secondary Accession #    Q5TBK8; Q6IBE9; B2R970 [Other Products]
 UniProt Related Accession #    P15374 [Other Products]
 Molecular Weight    26,183 Da
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2
 NCBI Official Synonym Full Names    ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
 NCBI Official Symbol    UCHL3 [Similar Products]
 NCBI Official Synonym Symbols   
UCH-L3
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L3; ubiquitin thiolesterase; ubiquitin thioesterase L3
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L3
 UniProt Synonym Protein Names   
Ubiquitin thioesterase L3
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    UCHL3 [Similar Products]
 UniProt Synonym Gene Names    UCH-L3 [Similar Products]
 UniProt Entry Name    UCHL3_HUMAN
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 NCBI Summary for UCHL3    The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
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 UniProt Comments for UCHL3    UCHL3: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates. Highly expressed in heart, skeletal muscle, and testis. Inhibited by monoubiquitin and diubiquitin. Belongs to the peptidase C12 family.

Protein type: Protease; Ubiquitin conjugating system; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 13q22.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: peptidase activity; ubiquitin binding; protein binding; ubiquitin-specific protease activity

Biological Process: ubiquitin-dependent protein catabolic process; protein catabolic process
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 Research Articles on UCHL3    1. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UCHL3 antibodyPathways associated with anti-UCHL3 antibody
 Reference Product  PubMed Publications
 LMO7 antibody  >3 publications with UCHL3 and LMO7
 NEDD8 antibody  >3 publications with UCHL3 and NEDD8
 UBB antibody  >1 publications with UCHL3 and UBB
 Products by Pathway  Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
Diseases associated with anti-UCHL3 antibodyOrgans/Tissues associated with anti-UCHL3 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with UCHL3 and Brain Diseases
 Urogenital Abnormalities Antibodies  >2 publications with UCHL3 and Urogenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with UCHL3 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with UCHL3 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with UCHL3 and Cell Transformation, Neoplastic
 Learning Disorders Antibodies  >1 publications with UCHL3 and Learning Disorders
 Atrophy Antibodies  >1 publications with UCHL3 and Atrophy
 Liver Diseases Antibodies  >1 publications with UCHL3 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with UCHL3 and Liver Neoplasms
 Cognition Disorders Antibodies  >1 publications with UCHL3 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with UCHL3 and Brain
 Muscle Antibodies  >6 publications with UCHL3 and Muscle
 Embryonic Tissue Antibodies  >4 publications with UCHL3 and Embryonic Tissue
 Liver Antibodies  >2 publications with UCHL3 and Liver
 Connective Tissue Antibodies  >2 publications with UCHL3 and Connective Tissue
 Testis Antibodies  >2 publications with UCHL3 and Testis
 Bone Antibodies  >2 publications with UCHL3 and Bone
 Kidney Antibodies  >2 publications with UCHL3 and Kidney
 Eye Antibodies  >1 publications with UCHL3 and Eye
 Lung Antibodies  >1 publications with UCHL3 and Lung
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