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anti-UCP1 antibody :: Goat UCP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420174
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-UCP1 Antibody

 Product Synonym Names    UCP1; uncoupling protein 1 (mitochondrial, proton carrier); HGNC: 12517; SLC25A7; UCP; mitochondrial brown fat uncoupling protein; uncoupling protein 1; UCP1 antibody; uncoupling protein 1 (mitochondrial; proton carrier) antibody; HGNC: 12517 antibody; SLC25A7 antibody; UCP antibody; mitochondrial brown fat uncoupling protein antibody; uncoupling protein 1 antibody
 Product Gene Name   

anti-UCP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    UCP1 peptide (MBS425317) is used for blocking the activity of UCP1 antibody (MBS420174)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EQLKRELSKS RQ
 OMIM    113730
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EQLKRELSKSRQ, from the C Terminus of the protein sequence according to NP_068605.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-UCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UCP1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-UCP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 35kDa band observed in Human Adipose lysates (calculated MW of 33. 0kDa according to NP_068605.1). Recommended concentration: 0.1-1 ug/ml.
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 Western Blot (WB) of anti-UCP1 antibody    (1ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-UCP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UCP1. It may not necessarily be applicable to this product.
 NCBI GI #    11225256
 NCBI GeneID    7350
 NCBI Accession #    NP_068605.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021833.4 [Other Products]
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 UniProt Secondary Accession #    Q13218; Q4KMZ3; Q68G66 [Other Products]
 UniProt Related Accession #    P25874 [Other Products]
 Molecular Weight    33,005 Da
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 NCBI Official Full Name    mitochondrial brown fat uncoupling protein 1
 NCBI Official Synonym Full Names    uncoupling protein 1
 NCBI Official Symbol    UCP1 [Similar Products]
 NCBI Official Synonym Symbols   
UCP; SLC25A7
[Similar Products]
 NCBI Protein Information    mitochondrial brown fat uncoupling protein 1
 UniProt Protein Name    Mitochondrial brown fat uncoupling protein 1
 UniProt Synonym Protein Names   
Solute carrier family 25 member 7; Thermogenin
 Protein Family    Mitochondrial brown fat uncoupling protein
 UniProt Gene Name    UCP1 [Similar Products]
 UniProt Synonym Gene Names    SLC25A7; UCP; UCP 1 [Similar Products]
 UniProt Entry Name    UCP1_HUMAN
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 NCBI Summary for UCP1    Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UCP1    UCP1: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q28-q31

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function: oxidative phosphorylation uncoupler activity; structural constituent of ribosome

Biological Process: brown fat cell differentiation; mitochondrial transport; proton transport; regulation of transcription from RNA polymerase II promoter; translation

Disease: Obesity
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 Research Articles on UCP1    1. 1-3826 A>G polymorphism associated with elevated lipid and apolipoprotein levels in Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UCP1 antibodyPathways associated with anti-UCP1 antibody
 Reference Product  PubMed Publications
 PPARGC1A antibody  >108 publications with UCP1 and PPARGC1A
 CIDEA antibody  >54 publications with UCP1 and CIDEA
 NPY antibody  >31 publications with UCP1 and NPY
 FNDC5 antibody  >17 publications with UCP1 and FNDC5
 ADRB3 antibody  >17 publications with UCP1 and ADRB3
 PPARG antibody  >9 publications with UCP1 and PPARG
 INS antibody  >9 publications with UCP1 and INS
 LEP antibody  >9 publications with UCP1 and LEP
 PPARA antibody  >7 publications with UCP1 and PPARA
 RETN antibody  >4 publications with UCP1 and RETN
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Mitochondrial Uncoupling Proteins Pathway antibodies  Mitochondrial Uncoupling Proteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
Diseases associated with anti-UCP1 antibodyOrgans/Tissues associated with anti-UCP1 antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >623 publications with UCP1 and Obesity
 Insulin Resistance Antibodies  >132 publications with UCP1 and Insulin Resistance
 Weight Gain Antibodies  >124 publications with UCP1 and Weight Gain
 Weight Loss Antibodies  >90 publications with UCP1 and Weight Loss
 Fatty Liver Antibodies  >76 publications with UCP1 and Fatty Liver
 Inflammation Antibodies  >58 publications with UCP1 and Inflammation
 Cardiovascular Diseases Antibodies  >39 publications with UCP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >35 publications with UCP1 and Disease Models, Animal
 Liver Diseases Antibodies  >31 publications with UCP1 and Liver Diseases
 Hyperglycemia Antibodies  >27 publications with UCP1 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >1134 publications with UCP1 and Adipose Tissue
 Connective Tissue Antibodies  >790 publications with UCP1 and Connective Tissue
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