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anti-UCP2 antibody :: Rabbit anti-Murine UCP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535066 anti-UCP2 antibody
Unit / Price
0.1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCP2, Polyclonal Antibody

 Also Known As   

UCP2 antibody

 Product Synonym Names    Polyclonal UCP2; Anti-UCP2; UCP 2; Uncoupling Protein 2; UCP2; UCP-2; UCP -2
 Product Gene Name   

anti-UCP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601693
 3D Structure    ModBase 3D Structure for P55851
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Murine
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 Purity/Purification    UCP2 antibody was purified by affinity chromatography.
 Form/Format    Affinity purified antibody lyophilized from 100mM Tris, pH 7.5, with 0.2% BSA, and 0.05% NaN3. Reconstitute in 100 ul of water, do not dilute further until ready to use.
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 Biological Significance    Uncoupling proteins (UCP1-5) are a family of mitochondria transport proteins that play a critical role in thermoregulatory heat production and maintenance of basal metabolic rate. UCP3 is predicted to contain 6 transmembrane domains. The UCP3S lacks the 6th transmembrane domain and it is only 275 aa long. Mouse/rat UCP2 is A 309 AA (human 309 aa chromosome 7; ~95% homology) mitochondrial uncoupling protein. UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation.
 Immunogen    UCP2 antibody was raised in rabbit using a 14 amino acid peptide from mouse UCP2 as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-UCP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-UCP2 antibody

   Rabbit polyclonal UCP2 antibody
 Product Categories/Family for anti-UCP2 antibody    Nutrition & Metabolism
 Applications Tested/Suitable for anti-UCP2 antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-UCP2 antibody    ELISA: 1:10,000-1:100,000
IF: 2-20 ug/ml
WB: 1-10 ug/ml
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NCBI/Uniprot data below describe general gene information for UCP2. It may not necessarily be applicable to this product.
 NCBI GI #    1877474
 NCBI GeneID    7351
 NCBI Accession #    AAC51336.1 [Other Products]
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 UniProt Primary Accession #    P55851 [Other Products]
 UniProt Secondary Accession #    Q4PJH8; Q53HM3 [Other Products]
 UniProt Related Accession #    P55851 [Other Products]
 Molecular Weight    33,229 Da
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 NCBI Official Full Name    UCP2
 NCBI Official Synonym Full Names    uncoupling protein 2 (mitochondrial, proton carrier)
 NCBI Official Symbol    UCP2 [Similar Products]
 NCBI Official Synonym Symbols   
UCPH; BMIQ4; SLC25A8
[Similar Products]
 NCBI Protein Information    mitochondrial uncoupling protein 2
 UniProt Protein Name    Mitochondrial uncoupling protein 2
 UniProt Synonym Protein Names   
Solute carrier family 25 member 8; UCPH
 UniProt Gene Name    UCP2 [Similar Products]
 UniProt Synonym Gene Names    SLC25A8; UCP 2 [Similar Products]
 UniProt Entry Name    UCP2_HUMAN
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 NCBI Summary for UCP2    Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UCP2    UCP2: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: mitochondrial inner membrane; integral to membrane

Biological Process: cellular metabolic process; response to superoxide; proton transport; regulation of mitochondrial membrane potential; cellular response to insulin stimulus; cellular response to amino acid starvation; transport; response to hypoxia; female pregnancy; negative regulation of apoptosis; aging; mitochondrial transport

Disease: Body Mass Index Quantitative Trait Locus 4
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 Research Articles on UCP2    1. 72% of the patients had risk combination of PGC-1alpha XA and UCP2-866 XA genotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UCP2 antibodyPathways associated with anti-UCP2 antibody
 Reference Product  PubMed Publications
 UCP3 antibody  >429 publications with UCP2 and UCP3
 UCP1 antibody  >314 publications with UCP2 and UCP1
 PPARG antibody  >77 publications with UCP2 and PPARG
 INS antibody  >51 publications with UCP2 and INS
 SIRT1 antibody  >21 publications with UCP2 and SIRT1
 PPARA antibody  >11 publications with UCP2 and PPARA
 LEP antibody  >9 publications with UCP2 and LEP
 NRF1 antibody  >7 publications with UCP2 and NRF1
 GHRL antibody  >2 publications with UCP2 and GHRL
 FOXA2 antibody  >1 publications with UCP2 and FOXA2
 Products by Pathway  Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Mitochondrial Uncoupling Proteins Pathway antibodies  Mitochondrial Uncoupling Proteins Pathway Diagram
 Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
 The Fatty Acid Cycling Model Pathway antibodies  The Fatty Acid Cycling Model Pathway Diagram
 The Proton Buffering Model Pathway antibodies  The Proton Buffering Model Pathway Diagram
Diseases associated with anti-UCP2 antibodyOrgans/Tissues associated with anti-UCP2 antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >356 publications with UCP2 and Obesity
 Fatty Liver Antibodies  >108 publications with UCP2 and Fatty Liver
 Cardiovascular Diseases Antibodies  >104 publications with UCP2 and Cardiovascular Diseases
 Insulin Resistance Antibodies  >103 publications with UCP2 and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >100 publications with UCP2 and Diabetes Mellitus, Type 2
 Disease Models, Animal Antibodies  >91 publications with UCP2 and Disease Models, Animal
 Inflammation Antibodies  >77 publications with UCP2 and Inflammation
 Nervous System Diseases Antibodies  >63 publications with UCP2 and Nervous System Diseases
 Liver Diseases Antibodies  >60 publications with UCP2 and Liver Diseases
 Necrosis Antibodies  >57 publications with UCP2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >361 publications with UCP2 and Adipose Tissue
 Muscle Antibodies  >335 publications with UCP2 and Muscle
 Blood Antibodies  >274 publications with UCP2 and Blood
 Connective Tissue Antibodies  >245 publications with UCP2 and Connective Tissue
 Liver Antibodies  >216 publications with UCP2 and Liver
 Brain Antibodies  >151 publications with UCP2 and Brain
 Pancreas Antibodies  >118 publications with UCP2 and Pancreas
 Heart Antibodies  >117 publications with UCP2 and Heart
 Vascular Antibodies  >54 publications with UCP2 and Vascular
 Kidney Antibodies  >45 publications with UCP2 and Kidney
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