AAC18822.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,874 Da
NCBI Official Full Name
uncoupling protein 3
NCBI Official Synonym Full Names
uncoupling protein 3 (mitochondrial, proton carrier)
NCBI Official Synonym Symbols
NCBI Protein Information
mitochondrial uncoupling protein 3
UniProt Protein Name
Mitochondrial uncoupling protein 3
UniProt Synonym Protein Names
Solute carrier family 25 member 9
UniProt Synonym Gene Names
UniProt Entry Name
UCP3_HUMAN
NCBI Summary for UCP3
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Comments for UCP3
UCP3: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. Defects in UCP3 may be involved in obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane
Molecular Function: protein binding; transporter activity; oxidative phosphorylation uncoupler activity
Biological Process: response to superoxide; response to glucocorticoid stimulus; respiratory gaseous exchange; fatty acid metabolic process; cellular response to hormone stimulus; mitochondrial transport; response to insulin stimulus; cellular metabolic process; proton transport; response to hypoxia; response to cold; response to activity; lipid metabolic process; response to nutrient; aging
Disease: Obesity
Research Articles on UCP3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-UCP3 antibody
Pathways associated with anti-UCP3 antibody
Diseases associated with anti-UCP3 antibody
Organs/Tissues associated with anti-UCP3 antibody
|