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anti-UNC93B antibody :: Rabbit UNC93B / UNC93B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242310
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UNC93B / UNC93B1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human UNC93B / UNC93B1

 Product Synonym Names    Anti-UNC93B / UNC93B1 Antibody (N-Terminus) IHC-plus; UNC93B1; IIAE1; Unc-93 homolog B1 (C. elegans); UNC93; UNC93B; Protein unc-93 homolog B1; Unc93 homolog B; HUNC93B1; Unc-93 related protein; Unc-93B1; Unc93 (C. elegans) homolog B1; Unc93 homolog B1; Human UNC93B; UNC93B1
 Product Gene Name   

anti-UNC93B antibody

[Similar Products]
 Product Synonym Gene Name    UNC93B1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610551
 3D Structure    ModBase 3D Structure for Q9H1C4
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    19 amino acid peptide from near the amino terminus of human Unc93b.
 Immunogen    UNC93B / UNC93B1 antibody was raised against 19 amino acid peptide from near the amino terminus of human Unc93b.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-UNC93B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UNC93B antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-UNC93B antibody    ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-UNC93B antibody    Anti-UNC93B1 / UNC93B antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-UNC93B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-UNC93B antibody    Immunofluorescence of Unc93b in Human Heart cells with Unc93b antibody at 20 ug/ml.
anti-UNC93B antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-UNC93B antibody    Western blot of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
anti-UNC93B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UNC93B. It may not necessarily be applicable to this product.
 NCBI GI #    45580709
 NCBI GeneID    81622
 NCBI Accession #    NP_112192.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030930.3 [Other Products]
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 UniProt Primary Accession #    Q9H1C4 [Other Products]
 UniProt Secondary Accession #    O95764; Q569H6; Q710D4 [Other Products]
 UniProt Related Accession #    Q9H1C4 [Other Products]
 Molecular Weight    66,631 Da
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 NCBI Official Full Name    protein unc-93 homolog B1
 NCBI Official Synonym Full Names    unc-93 homolog B1 (C. elegans)
 NCBI Official Symbol    UNC93B1 [Similar Products]
 NCBI Official Synonym Symbols   
IIAE1; UNC93; UNC93B; Unc-93B1
[Similar Products]
 NCBI Protein Information    protein unc-93 homolog B1; unc93 homolog B1; unc-93 related protein
 UniProt Protein Name    Protein unc-93 homolog B1
 UniProt Gene Name    UNC93B1 [Similar Products]
 UniProt Synonym Gene Names    UNC93; UNC93B; Unc-93B1; hUNC93B1 [Similar Products]
 UniProt Entry Name    UN93B_HUMAN
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 NCBI Summary for UNC93B    This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]
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 UniProt Comments for UNC93B    UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family.

Protein type: Membrane protein, multi-pass; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; lysosome; endoplasmic reticulum; integral to membrane; endosome

Biological Process: intracellular protein transport; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus

Disease: Herpes Simplex Encephalitis, Susceptibility To, 1
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 Research Articles on UNC93B    1. the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UNC93B antibodyPathways associated with anti-UNC93B antibody
 Reference Product  PubMed Publications
 TLR9 antibody  >40 publications with UNC93B and TLR9
 TLR3 antibody  >38 publications with UNC93B and TLR3
 TLR7 antibody  >28 publications with UNC93B and TLR7
 TLR8 antibody  >8 publications with UNC93B and TLR8
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Trafficking And Processing Of Endosomal TLR Pathway antibodies  Trafficking And Processing Of Endosomal TLR Pathway Diagram
Diseases associated with anti-UNC93B antibodyOrgans/Tissues associated with anti-UNC93B antibody
 Disease Name  Pubmed Publications
 Encephalitis, Herpes Simplex Antibodies  >17 publications with UNC93B and Encephalitis, Herpes Simplex
 Inflammation Antibodies  >11 publications with UNC93B and Inflammation
 Nervous System Diseases Antibodies  >10 publications with UNC93B and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with UNC93B and Disease Models, Animal
 Necrosis Antibodies  >3 publications with UNC93B and Necrosis
 Nephritis Antibodies  >1 publications with UNC93B and Nephritis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with UNC93B and Blood
 Bone Antibodies  >6 publications with UNC93B and Bone
 Bone Marrow Antibodies  >6 publications with UNC93B and Bone Marrow
 Brain Antibodies  >5 publications with UNC93B and Brain
 Spleen Antibodies  >3 publications with UNC93B and Spleen
 Liver Antibodies  >2 publications with UNC93B and Liver
 Kidney Antibodies  >1 publications with UNC93B and Kidney
 Nerve Antibodies  >1 publications with UNC93B and Nerve
 Intestine Antibodies  >1 publications with UNC93B and Intestine
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