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anti-UNC93B1 antibody :: Rabbit UNC93B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6001659 anti-UNC93B1 antibody
Unit / Price
0.1 mg  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UNC93B1, Polyclonal Antibody

 Also Known As   

UNC93B1 (Protein Unc-93 Homolog B1, Unc-93B1, hUNC93B1, UNC93, UNC93B)

 Product Synonym Names    Anti -UNC93B1 (Protein Unc-93 Homolog B1, Unc-93B1, hUNC93B1, UNC93, UNC93B)
 Product Gene Name   

anti-UNC93B1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (67758575..67771593, complement). Location: 11q13
 OMIM    608204
 3D Structure    ModBase 3D Structure for Q9H1C4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes mouse UNC93B. Species Crossreactivity
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
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 Immunogen    Synthetic peptide corresponding to aa500-550 of mouse UNC93B protein.
 Positive Control    Spleen lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-UNC93B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-UNC93B1 antibody

   UNC93B is a member of a novel hUNC93B-related gene family and encodes a 12-membrane-spanning protein related to unc-93 of Caenorhabditis elegans. The protein is involved in the regulation or coordination of muscle contraction in the worm. The protein is also necessary for TLR signaling and for the presentation and cross-presentation of exogenous antigens. The protein specifically interacts with TLR3, 7, 9, and 13 and introduction of point mutation H412R in UNC93B abolishes these interactions. Mutation in the missense allele of UNC93B, 3d disrupts exogenous antigen presentation and signaling via TLR. The pathological role of the protein has been identified in susceptibility to herpes simplex encephalitis (HSE). In human the protein is expressed in heart and at lower levels in kidney. In mouse the gene is localized in the chromosomal region 19 A.
 Product Categories/Family for anti-UNC93B1 antibody    Antibodies; Abs to Membrane Proteins
 Applications Tested/Suitable for anti-UNC93B1 antibody   

Western Blot (WB)

 Application Notes for anti-UNC93B1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 3-5ug/ml
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NCBI/Uniprot data below describe general gene information for UNC93B1. It may not necessarily be applicable to this product.
 NCBI GI #    62020730
 NCBI GeneID    81622
 NCBI Accession #    AAH25669.1 [Other Products]
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 UniProt Primary Accession #    Q9H1C4 [Other Products]
 UniProt Secondary Accession #    O95764; Q569H6; Q710D4 [Other Products]
 UniProt Related Accession #    Q9H1C4 [Other Products]
 Molecular Weight    66,631 Da [Similar Products]
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 NCBI Official Full Name    UNC93B1 protein, partial
 NCBI Official Synonym Full Names    unc-93 homolog B1 (C. elegans)
 NCBI Official Symbol    UNC93B1 [Similar Products]
 NCBI Official Synonym Symbols   
IIAE1; UNC93; UNC93B; Unc-93B1
[Similar Products]
 NCBI Protein Information    protein unc-93 homolog B1; hUNC93B1; unc93 homolog B; unc93 homolog B1; unc-93 related protein
 UniProt Protein Name    Protein unc-93 homolog B1
 Protein Family    Protein
 UniProt Gene Name    UNC93B1 [Similar Products]
 UniProt Synonym Gene Names    UNC93; UNC93B; Unc-93B1; hUNC93B1 [Similar Products]
 UniProt Entry Name    UN93B_HUMAN
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 NCBI Summary for UNC93B1    This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UNC93B1    UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family.

Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; lysosome; endoplasmic reticulum; integral to membrane; endosome

Biological Process: intracellular protein transport; toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus

Disease: Herpes Simplex Encephalitis, Susceptibility To, 1
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 Research Articles on UNC93B1    1. IgM(+)IgD(+)CD27(+) but not switched B cells were strongly reduced in MYD88-, IRAK-4-, and TIRAP-deficient patients, but not UNC-93B-deficient patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UNC93B1 antibodyPathways associated with anti-UNC93B1 antibody
 Reference Product  PubMed Publications
 TLR3 antibody  >34 publications with UNC93B1 and TLR3
 TLR9 antibody  >32 publications with UNC93B1 and TLR9
 TLR7 antibody  >24 publications with UNC93B1 and TLR7
 TLR8 antibody  >7 publications with UNC93B1 and TLR8
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Trafficking And Processing Of Endosomal TLR Pathway antibodies  Trafficking And Processing Of Endosomal TLR Pathway Diagram
Diseases associated with anti-UNC93B1 antibodyOrgans/Tissues associated with anti-UNC93B1 antibody
 Disease Name  Pubmed Publications
 Encephalitis, Herpes Simplex Antibodies  >15 publications with UNC93B1 and Encephalitis, Herpes Simplex
 Inflammation Antibodies  >10 publications with UNC93B1 and Inflammation
 Nervous System Diseases Antibodies  >9 publications with UNC93B1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with UNC93B1 and Disease Models, Animal
 Neoplasms Antibodies  >1 publications with UNC93B1 and Neoplasms
 Necrosis Antibodies  >1 publications with UNC93B1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with UNC93B1 and Blood
 Bone Antibodies  >6 publications with UNC93B1 and Bone
 Bone Marrow Antibodies  >6 publications with UNC93B1 and Bone Marrow
 Brain Antibodies  >5 publications with UNC93B1 and Brain
 Spleen Antibodies  >3 publications with UNC93B1 and Spleen
 Liver Antibodies  >2 publications with UNC93B1 and Liver
 Kidney Antibodies  >1 publications with UNC93B1 and Kidney
 Nerve Antibodies  >1 publications with UNC93B1 and Nerve
 Intestine Antibodies  >1 publications with UNC93B1 and Intestine
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