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anti-UNG antibody :: Rabbit UNG / Uracil DNA Glycosylase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241348
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UNG / Uracil DNA Glycosylase, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human UNG / Uracil DNA Glycosylase

 Product Synonym Names    Anti-UNG / Uracil DNA Glycosylase Antibody (N-Terminus) IHC-plus; UNG; DGU; HIGM4; HIGM5; Uracil-DNA glycosylase; UNG1; UNG2; UDG; UNG15; Human UNG; Uracil DNA Glycosylase
 Product Gene Name   

anti-UNG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 608106
 3D Structure    ModBase 3D Structure for P13051
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    13 amino acid peptide from near the amino terminus of human UNG1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human UNG.
 Immunogen Type    Synthetic peptide
 Immunogen    UNG / Uracil DNA Glycosylase antibody was raised against synthetic peptide from human UNG.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-UNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UNG antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-UNG antibody    IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-UNG antibody    Anti-UNG antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-UNG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-UNG antibody    Immunofluorescence of UNG1 in Human Heart cells with UNG1 antibody at 20 ug/ml.
anti-UNG antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-UNG antibody    Western blot of UNG1 in C2C12 cell lysate with UNG1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
anti-UNG antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for UNG. It may not necessarily be applicable to this product.
 NCBI GI #    6224979
 NCBI GeneID    7374
 NCBI Accession #    NP_003353.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003362.3 [Other Products]
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 UniProt Primary Accession #    P13051 [Other Products]
 UniProt Secondary Accession #    O00637; O00719; Q93028; A8K5M6; B2R8Y1 [Other Products]
 UniProt Related Accession #    P13051 [Other Products]
 Molecular Weight    33,924 Da
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 NCBI Official Full Name    uracil-DNA glycosylase isoform UNG1
 NCBI Official Synonym Full Names    uracil-DNA glycosylase
 NCBI Official Symbol    UNG [Similar Products]
 NCBI Official Synonym Symbols   
DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15
[Similar Products]
 NCBI Protein Information    uracil-DNA glycosylase; UDG; UNG; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
 UniProt Protein Name    Uracil-DNA glycosylase
 Protein Family    Probable uracil-DNA glycosylase
 UniProt Gene Name    UNG [Similar Products]
 UniProt Synonym Gene Names    [Similar Products]
 UniProt Entry Name    UNG_HUMAN
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 NCBI Summary for UNG    This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
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 UniProt Comments for UNG    UNG: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. Belongs to the uracil-DNA glycosylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.2.2.27

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; uracil DNA N-glycosylase activity

Biological Process: base-excision repair, AP site formation; viral reproduction; depyrimidination; base-excision repair; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; DNA repair; negative regulation of apoptosis

Disease: Immunodeficiency With Hyper-igm, Type 5
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 Research Articles on UNG    1. Data shows that cancer cells express UNG2 gene at levels similar to or higher than those seen with peripheral B cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UNG antibodyPathways associated with anti-UNG antibody
 Reference Product  PubMed Publications
 DUT antibody  >24 publications with UNG and DUT
 PCNA antibody  >13 publications with UNG and PCNA
 CCNO antibody  >10 publications with UNG and CCNO
 POLB antibody  >2 publications with UNG and POLB
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APE1 Pathway antibodies  Displacement Of DNA Glycosylase By APE1 Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-UNG antibodyOrgans/Tissues associated with anti-UNG antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >63 publications with UNG and Nervous System Diseases
 Breast Neoplasms Antibodies  >55 publications with UNG and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >27 publications with UNG and Cardiovascular Diseases
 Brain Diseases Antibodies  >27 publications with UNG and Brain Diseases
 Adenocarcinoma Antibodies  >25 publications with UNG and Adenocarcinoma
 Disease Models, Animal Antibodies  >23 publications with UNG and Disease Models, Animal
 Inflammation Antibodies  >20 publications with UNG and Inflammation
 Necrosis Antibodies  >18 publications with UNG and Necrosis
 Colorectal Neoplasms Antibodies  >14 publications with UNG and Colorectal Neoplasms
 Heart Diseases Antibodies  >12 publications with UNG and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >149 publications with UNG and Blood
 Lung Antibodies  >58 publications with UNG and Lung
 Brain Antibodies  >47 publications with UNG and Brain
 Lymph Node Antibodies  >44 publications with UNG and Lymph Node
 Lymph Antibodies  >41 publications with UNG and Lymph
 Bone Antibodies  >39 publications with UNG and Bone
 Liver Antibodies  >29 publications with UNG and Liver
 Eye Antibodies  >25 publications with UNG and Eye
 Mouth Antibodies  >22 publications with UNG and Mouth
 Heart Antibodies  >22 publications with UNG and Heart
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