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anti-USP30 antibody :: Rabbit anti-Human, mouse USP30 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7001025
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

USP30, Polyclonal Antibody

★Popular Item★
 Also Known As   

USP30 Antibody

 Product Synonym Names    Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.121 Publication; USP30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
 Product Gene Name   

anti-USP30 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612492
 3D Structure    ModBase 3D Structure for Q70CQ3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Ubiquitin carboxyl-terminal hydrolase 30 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109455
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-USP30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-USP30 antibody

   Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
 Applications Tested/Suitable for anti-USP30 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-USP30 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-USP30 antibody    Western blot
All lanes: USP30 antibody at 7ug/ml+ Mouse lung tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 59 kDa
Observed band size: 59 kDa

anti-USP30 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-USP30 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7001025 at dilution of 1:100
anti-USP30 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-USP30 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS7001025 at dilution of 1:100
anti-USP30 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for USP30. It may not necessarily be applicable to this product.
 NCBI GI #    667667715
 NCBI GeneID    84749
 NCBI Accession #    NP_001288104.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001301175.1 [Other Products]
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 UniProt Primary Accession #    Q70CQ3 [Other Products]
 UniProt Secondary Accession #    Q8WTU7; Q96JX4; Q9BSS3 [Other Products]
 UniProt Related Accession #    Q70CQ3 [Other Products]
 Molecular Weight    58,503 Da
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase 30 isoform 2
 NCBI Official Synonym Full Names    ubiquitin specific peptidase 30
 NCBI Official Symbol    USP30 [Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase 30
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase 30
 UniProt Synonym Protein Names   
Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    USP30 [Similar Products]
 UniProt Synonym Gene Names    Ub-specific protease 30 [Similar Products]
 UniProt Entry Name    UBP30_HUMAN
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 NCBI Summary for USP30    USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
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 UniProt Comments for USP30    USP30: May participate in the maintenance of mitochondrial morphology. Belongs to the peptidase C19 family.

Protein type: EC 3.4.19.12; Protease; Membrane protein, integral; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: mitochondrial fusion; mitochondrion degradation; protein deubiquitination; ubiquitin-dependent protein catabolic process
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 Research Articles on USP30    1. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-USP30 antibodyDiseases associated with anti-USP30 antibody
 Reference Product  PubMed Publications
 USP1 antibody  >1 publications with USP30 and USP1
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with USP30 and Nervous System Diseases
Organs/Tissues associated with anti-USP30 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with USP30 and Brain
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