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anti-USP4 antibody :: Rabbit anti-Human USP4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS629133 anti-USP4 antibody
Unit / Price
0.05 mg  /  $865 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

USP4, Polyclonal Antibody

 Also Known As   

USP4 (Ubiquitin Specific Peptidase 4 (Protooncogene), Ubiquitin-specific Peptidase 4 (Proto-oncogene), Ubiquitin Specific-processing Protease 4, Ubiquitin Specific Protease 4, Ubiquitin-specific Protease 4 (Proto-oncogene), Deubiquitinating Enzyme 4, MGC1

 Product Synonym Names    Anti -USP4 (Ubiquitin Specific Peptidase 4 (Protooncogene), Ubiquitin-specific Peptidase 4 (Proto-oncogene), Ubiquitin Specific-processing Protease 4, Ubiquitin Specific Protease 4, Ubiquitin-specific Protease 4 (Proto-oncogene), Deubiquitinating Enzyme 4, MGC1
 Product Gene Name   

anti-USP4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (49314577..49377536, complement). Location: 3p21.3
 3D Structure    ModBase 3D Structure for Q08AK7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes an epitope within the internal region of human USP4. Species sequence homology: mouse.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.02% sodium azide.
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 Immunogen    Synthetic peptide corresponding to the internal domain of human USP4.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-USP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-USP4 antibody

   USP4 is a 105kD protein also known as ubiquitous nuclear protein (UNP). USP4 binds to the retinoblastoma family of tumor suppressor proteins, including pRb, p107 and p130. USP4 shuttles between the nucleus and cytoplasm and is thought to be an oncogene, with elevated expression in small cells tumors and adenocarcinomas of the lung.
 Product Categories/Family for anti-USP4 antibody    Antibodies; Abs to Oncoproteins
 Applications Tested/Suitable for anti-USP4 antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-USP4 antibody    Suitable for use in Immunohistochemistry (paraffin).
Dilution: Immunohistochemistry (paraffin): 5-10ug/ml
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for USP4. It may not necessarily be applicable to this product.
 NCBI GI #    40795665
 NCBI GeneID    7375
 NCBI Accession #    NP_003354.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003363.3 [Other Products]
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 UniProt Primary Accession #    Q08AK7 [Other Products]
 UniProt Related Accession #    Q08AK7; Q13107; Q53FJ3; Q53H56 [Other Products]
 Molecular Weight    108,523 Da [Similar Products]
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase 4 isoform a
 NCBI Official Synonym Full Names    ubiquitin specific peptidase 4 (proto-oncogene)
 NCBI Official Symbol    USP4 [Similar Products]
 NCBI Official Synonym Symbols   
UNP; Unph; MGC149848; MGC149849
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase 4; OTTHUMP00000210715; OTTHUMP00000210716; OTTHUMP00000210717; ubiquitin thioesterase 4; deubiquitinating enzyme 4; ubiquitin thiolesterase 4; ubiquitous nuclear protein homolog; ubiquitin carboxyl-terminal esterase 4; ubiquitin-specific processing protease 4; ubiquitin-specific-processing protease 4; ubiquitin specific protease 4 (proto-oncogene)
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    USP4 [Similar Products]
 UniProt Entry Name    Q08AK7_HUMAN
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 NCBI Summary for USP4    The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for USP4    USP4: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER. Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with RB1, RBL1 and RBL2. Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung. Expressed in the hippocampal neurons. Belongs to the peptidase C19 family. USP4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: lysosome; cytoplasm; plasma membrane; nucleus

Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; metal ion binding; ubiquitin-specific protease activity; adenosine receptor binding

Biological Process: assembly of spliceosomal tri-snRNP; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of protein stability; negative regulation of protein ubiquitination
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 Research Articles on USP4    1. modulation of USP4 expression may provide a new means to interfere with canonical Wnt signalling in a variety of physiological and pathological conditions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-USP4 antibodyDiseases associated with anti-USP4 antibody
 Reference Product  PubMed Publications
 RBL1 antibody  >1 publications with USP4 and RBL1
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with USP4 and Neoplasms
 Carcinoma Antibodies  >4 publications with USP4 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with USP4 and Adenocarcinoma
 Lung Neoplasms Antibodies  >2 publications with USP4 and Lung Neoplasms
 Adrenal Gland Neoplasms Antibodies  >2 publications with USP4 and Adrenal Gland Neoplasms
 Adrenocortical Adenoma Antibodies  >2 publications with USP4 and Adrenocortical Adenoma
 Adenoma Antibodies  >2 publications with USP4 and Adenoma
 Lung Diseases Antibodies  >2 publications with USP4 and Lung Diseases
 Prostatic Neoplasms Antibodies  >1 publications with USP4 and Prostatic Neoplasms
 Anemia Antibodies  >1 publications with USP4 and Anemia
Organs/Tissues associated with anti-USP4 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with USP4 and Lung
 Kidney Antibodies  >2 publications with USP4 and Kidney
 Embryonic Tissue Antibodies  >2 publications with USP4 and Embryonic Tissue
 Thyroid Antibodies  >1 publications with USP4 and Thyroid
 Spleen Antibodies  >1 publications with USP4 and Spleen
 Thymus Antibodies  >1 publications with USP4 and Thymus
 Stomach Antibodies  >1 publications with USP4 and Stomach
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