NP_003354.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 4 isoform a
NCBI Official Synonym Full Names
ubiquitin specific peptidase 4 (proto-oncogene)
NCBI Official Synonym Symbols
UNP; Unph; MGC149848; MGC149849 [Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 4; OTTHUMP00000210715; OTTHUMP00000210716; OTTHUMP00000210717; ubiquitin thioesterase 4; deubiquitinating enzyme 4; ubiquitin thiolesterase 4; ubiquitous nuclear protein homolog; ubiquitin carboxyl-terminal esterase 4; ubiquitin-specific processing protease 4; ubiquitin-specific-processing protease 4; ubiquitin specific protease 4 (proto-oncogene)
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase
UniProt Entry Name
Q08AK7_HUMAN
NCBI Summary for USP4
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for USP4
USP4: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER. Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with RB1, RBL1 and RBL2. Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung. Expressed in the hippocampal neurons. Belongs to the peptidase C19 family. USP4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease; Oncoprotein
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: lysosome; cytoplasm; plasma membrane; nucleus
Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; metal ion binding; ubiquitin-specific protease activity; adenosine receptor binding
Biological Process: assembly of spliceosomal tri-snRNP; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of protein stability; negative regulation of protein ubiquitination
Research Articles on USP4
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Products associated with anti-USP4 antibody
Diseases associated with anti-USP4 antibody
Organs/Tissues associated with anti-USP4 antibody
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