NP_001240804.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
UDP-glucuronic acid decarboxylase 1 isoform 1
NCBI Official Synonym Full Names
UDP-glucuronate decarboxylase 1
NCBI Official Synonym Symbols
NCBI Protein Information
UDP-glucuronic acid decarboxylase 1
UniProt Protein Name
UDP-glucuronic acid decarboxylase 1
UniProt Synonym Protein Names
UDP-glucuronate decarboxylase 1; UGD; UXS-1
UniProt Synonym Gene Names
UniProt Entry Name
UXS1_HUMAN
NCBI Summary for UXS1
This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for UXS1
UXS1: Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - starch and sucrose; Membrane protein, integral; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Lyase; EC 4.1.1.35
Chromosomal Location of Human Ortholog: 2q12.2
Cellular Component: mitochondrion; integral to membrane
Molecular Function: UDP-glucuronate decarboxylase activity; protein homodimerization activity
Biological Process: UDP-D-xylose biosynthetic process; protein tetramerization
Product References and Citations for anti-UXS1 antibody
Bailey, S.D., et al. Diabetes Care (2010) In press : Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) : Bakker, H., et al. J. Biol. Chem. 284(4):2576-2583(2009)
Research Articles on UXS1
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Pathways associated with anti-UXS1 antibody
Diseases associated with anti-UXS1 antibody
Organs/Tissues associated with anti-UXS1 antibody
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