NP_001243284.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,004 Da
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 L3 isoform 4
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 L3
NCBI Protein Information
ubiquitin-conjugating enzyme E2 L3
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 L3
UniProt Synonym Protein Names
E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3
UniProt Synonym Gene Names
NCBI Summary for UBE2L3
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for UBE2L3
UBE2L3: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1. Ubiquitous, with highest expression in testis. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: ATP binding; enzyme binding; protein binding; RNA binding; transcription coactivator activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process: cell proliferation; cellular protein modification process; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein transferase activity; protein polyubiquitination; protein ubiquitination; regulation of transcription, DNA-templated; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
Research Articles on UBE2L3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-UBE2L3 antibody
Pathways associated with anti-UBE2L3 antibody
Diseases associated with anti-UBE2L3 antibody
Organs/Tissues associated with anti-UBE2L3 antibody
|