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anti-RPS27A antibody :: Rabbit anti-Bovine Ubiquitin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS560605 anti-RPS27A antibody
Unit / Price
1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ubiquitin (RPS27A), Polyclonal Antibody

 Also Known As   

Rabbit anti-Ubiquitin (Bovine)

 Product Synonym Names    Rabbit anti-Bovine Ubiquitin; anti-Bovine Ubiquitin
 Product Gene Name   

anti-RPS27A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (55459039..55462989). Location: 2p16
 OMIM    191343
 3D Structure    ModBase 3D Structure for P62979
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine
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 Form/Format    Whole Serum
Physical State: Liquid
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 Preservative    0.1% sodium azide
 Procedure    Rabbits were immunized with purified bovine ubiquitin coupled with KLH and serum was collected.
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 Preparation and Storage    Store at 4 degree C.
Shelf Life: 12 months from shipment date
 Other Notes    Small volumes of anti-RPS27A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPS27A antibody

   Rabbits were immunized with purified bovine ubiquitin.
 Product Categories/Family for anti-RPS27A antibody    Bovine Protein
 Application Notes for anti-RPS27A antibody    This polyclonal antibody reacts with ubiquitin by ELISA and western blot. Suggested starting dilution: ELISA = 1:500 Blotting = 1:150. Optimal working dilutions should be determined for your particular assay conditions.
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NCBI/Uniprot data below describe general gene information for RPS27A. It may not necessarily be applicable to this product.
 NCBI GI #    37571
 NCBI GeneID    6233
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 UniProt Primary Accession #    P62979 [Other Products]
 UniProt Secondary Accession #    P02248; P02249; P02250; P14798; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888 [Other Products]
 UniProt Related Accession #    P62979; Q49A90; Q5RKT7; Q8WYN9 [Other Products]
 Molecular Weight    17,965 Da [Similar Products]
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 NCBI Official Full Name    ubiquitin
 NCBI Official Synonym Full Names    ribosomal protein S27a
 NCBI Official Symbol    RPS27A [Similar Products]
 NCBI Official Synonym Symbols   
UBC; S27A; CEP80; UBA80; UBCEP1; UBCEP80
[Similar Products]
 NCBI Protein Information    ubiquitin-40S ribosomal protein S27a; ubiquitin C; ubiquitin-CEP80; OTTHUMP00000200786; OTTHUMP00000200788; OTTHUMP00000200789; OTTHUMP00000201692; ubiquitin and ribosomal protein S27a; ubiquitin carboxyl extension protein 80
 UniProt Protein Name    Ubiquitin-40S ribosomal protein S27a
 UniProt Synonym Protein Names   
Ubiquitin carboxyl extension protein 80
 Protein Family    Ubiquitin
 UniProt Gene Name    RPS27A [Similar Products]
 UniProt Synonym Gene Names    UBA80; UBCEP1 [Similar Products]
 UniProt Entry Name    RS27A_HUMAN
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 NCBI Summary for RPS27A    Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq]
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 UniProt Comments for RPS27A    RPS27A: the gene (RPS27A) that encodes this protein is one of four that encode for ubiquitin: UBC, UBB, UBA52 and RPS27A. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. The RPS27A gene product is cleaved into the following 2 chains: ubiquitin (amino acids 1-76) and the 40S ribosomal protein S27a (amino acids 77-156). Ubiquitin is a peptide 76 amino acids in length that can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Hundreds of ubiquitin ligases and hydrolases have been identified, implicating ubiquitin as a major regulatory element in many crucial cellular systems. It can be covalently bound to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. At the protein level, it is not possible to easily determine which of the four genes encoded a given ubiquitin chain.

Protein type: Ubiquitin-like modifier; Ribosomal

Chromosomal Location of Human Ortholog: 2p16

Cellular Component: nucleoplasm; small ribosomal subunit; membrane; cytoplasm; nucleolus; plasma membrane; endosome membrane; cytosol

Molecular Function: structural constituent of ribosome; metal ion binding

Biological Process: circadian rhythm; SRP-dependent cotranslational protein targeting to membrane; I-kappaB kinase/NF-kappaB cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; endosome transport; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of apoptosis; toll-like receptor 5 signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; transforming growth factor beta receptor signaling pathway; translational initiation; antigen processing and presentation of exogenous peptide antigen via MHC class I; JNK cascade; viral transcription; G2/M transition of mitotic cell cycle; toll-like receptor 4 signaling pathway; regulation of interferon type I production; glycogen biosynthetic process; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; Notch receptor processing; glucose metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; virus assembly; toll-like receptor 2 signaling pathway; translational elongation; carbohydrate metabolic process; mRNA catabolic process, nonsense-mediated decay; viral protein processing; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of interferon type I production; negative regulation of apoptosis; G1/S transition of mitotic cell cycle; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; translation; apoptosis; pathogenesis; negative regulation of transcription from RNA polymerase II promoter; viral infectious cycle; translational termination; toll-like receptor 10 signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of interferon type I production; transmembrane transport; epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; DNA repair; MyD88-dependent toll-like receptor signaling pathway; cellular protein metabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; toll-like receptor signaling pathway; innate immune response; gene expression; mitotic cell cycle; negative regulation of transforming growth factor beta receptor signaling pathway
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 Research Articles on RPS27A    1. ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RPS27A antibodyDiseases associated with anti-RPS27A antibody
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >2 publications with RPS27A and Abnormalities, Multiple
 Anemia, Aplastic Antibodies  >2 publications with RPS27A and Anemia, Aplastic
 Hematologic Diseases Antibodies  >2 publications with RPS27A and Hematologic Diseases
 Anemia Antibodies  >2 publications with RPS27A and Anemia
 Bone Marrow Diseases Antibodies  >2 publications with RPS27A and Bone Marrow Diseases
 Congenital Abnormalities Antibodies  >2 publications with RPS27A and Congenital Abnormalities
 Craniofacial Abnormalities Antibodies  >2 publications with RPS27A and Craniofacial Abnormalities
 Prostatic Neoplasms Antibodies  >1 publications with RPS27A and Prostatic Neoplasms
 Jaw Abnormalities Antibodies  >1 publications with RPS27A and Jaw Abnormalities
 Musculoskeletal Abnormalities Antibodies  >1 publications with RPS27A and Musculoskeletal Abnormalities
Organs/Tissues associated with anti-RPS27A antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with RPS27A and Brain
 Bone Antibodies  >1 publications with RPS27A and Bone
 Kidney Antibodies  >1 publications with RPS27A and Kidney
 Blood Antibodies  >1 publications with RPS27A and Blood
 Heart Antibodies  >1 publications with RPS27A and Heart
 Bone Marrow Antibodies  >1 publications with RPS27A and Bone Marrow
 Prostate Antibodies  >1 publications with RPS27A and Prostate
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