NP_444277.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,961 Da
NCBI Official Full Name
urocortin-3 preproprotein
NCBI Official Synonym Full Names
urocortin 3
NCBI Protein Information
urocortin-3; ucn III; stresscopin; urocortin III; prepro-urocortin 3
UniProt Protein Name
Urocortin-3
UniProt Synonym Protein Names
Stresscopin; Urocortin III
UniProt Synonym Gene Names
UniProt Entry Name
UCN3_HUMAN
NCBI Summary for UCN3
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
UniProt Comments for UCN3
UCN3: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: extracellular space; nerve terminal
Molecular Function: G-protein-coupled receptor binding; hormone activity; corticotropin-releasing hormone receptor 2 binding
Biological Process: response to starvation; cellular response to nutrient levels; digestion; response to glucose stimulus; positive regulation of insulin secretion; positive regulation of membrane potential; G-protein signaling, adenylate cyclase activating pathway; response to corticosterone stimulus
Research Articles on UCN3
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Products associated with anti-UCN3 antibody
Diseases associated with anti-UCN3 antibody
Organs/Tissues associated with anti-UCN3 antibody
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