NP_112540.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
urocortin-3 preproprotein
NCBI Official Synonym Full Names
urocortin 3
NCBI Official Synonym Symbols
NCBI Protein Information
urocortin-3
UniProt Protein Name
Urocortin-3
UniProt Synonym Protein Names
Urocortin III; Ucn III
UniProt Synonym Gene Names
NCBI Summary for UCN3
This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]
UniProt Comments for UCN3
UCN3: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13|13 A1
Cellular Component: axon; axon terminus; extracellular region; extracellular space; neuron projection
Molecular Function: corticotropin-releasing hormone receptor 2 binding; G-protein coupled receptor binding; hormone activity; neuropeptide hormone activity; protein binding
Biological Process: adenylate cyclase-activating G-protein coupled receptor signaling pathway; cellular response to nutrient levels; digestion; neuropeptide signaling pathway; positive regulation of insulin secretion; positive regulation of membrane potential; response to stress
Research Articles on UCN3
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Products associated with anti-UCN3 antibody
Pathways associated with anti-UCN3 antibody
Diseases associated with anti-UCN3 antibody
Organs/Tissues associated with anti-UCN3 antibody
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