NP_003344.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
urocortin preproprotein
NCBI Official Synonym Full Names
urocortin
NCBI Official Synonym Symbols
NCBI Protein Information
urocortin
UniProt Protein Name
Urocortin
NCBI Summary for UCN
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
UniProt Comments for UCN
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (). Reduces food intake and regulates ghrelin levels in gastric body and plasma ().
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Products associated with anti-UCN antibody
Diseases associated with anti-UCN antibody
Organs/Tissues associated with anti-UCN antibody
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