NP_034283.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
147,613 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-3
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 3
NCBI Protein Information
receptor tyrosine-protein kinase erbB-3
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-3
UniProt Synonym Protein Names
Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3
UniProt Comments for ErbB3
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 10 D3|10 77.1 cM
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral component of membrane; lateral plasma membrane; membrane; nucleus; postsynaptic membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: cranial nerve development; endocardial cushion development; epidermal growth factor receptor signaling pathway; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphorylation; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of glucose import; protein amino acid phosphorylation; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ErbB3
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Products associated with anti-ErbB3 antibody
Pathways associated with anti-ErbB3 antibody
Diseases associated with anti-ErbB3 antibody
Organs/Tissues associated with anti-ErbB3 antibody
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