NP_001005915.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,426 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-3 isoform s
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 3
NCBI Official Synonym Symbols
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 [Similar Products]
NCBI Protein Information
receptor tyrosine-protein kinase erbB-3
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-3
UniProt Synonym Protein Names
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
UniProt Synonym Gene Names
NCBI Summary for ErbB3
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ErbB3
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral component of plasma membrane; intracellular; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; neuregulin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor activity; ubiquitin protein ligase binding
Biological Process: cranial nerve development; endocardial cushion development; ERBB2 signaling pathway; heart development; MAPK cascade; negative regulation of cell adhesion; negative regulation of ERBB signaling pathway; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol phosphorylation; phosphoinositide 3-kinase cascade; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; regulation of cell motility; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Disease: Lethal Congenital Contracture Syndrome 2
Research Articles on ErbB3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-ErbB3 antibody
Pathways associated with anti-ErbB3 antibody
Diseases associated with anti-ErbB3 antibody
Organs/Tissues associated with anti-ErbB3 antibody
|