AAV38260.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,860 Da
NCBI Official Full Name
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
NCBI Official Synonym Full Names
ETS proto-oncogene 1, transcription factor
NCBI Protein Information
protein C-ets-1
UniProt Protein Name
Protein C-ets-1
UniProt Synonym Protein Names
p54
UniProt Synonym Gene Names
NCBI Summary for ETS1
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
UniProt Comments for ETS1
Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11q24.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; protein binding; transcription factor activity
Biological Process: cell motility involved in cell locomotion; immune response; negative regulation of cell proliferation; PML body organization and biogenesis; positive regulation of cell motility; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of angiogenesis
Research Articles on ETS1
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Products associated with anti-ETS1 antibody
Pathways associated with anti-ETS1 antibody
Diseases associated with anti-ETS1 antibody
Organs/Tissues associated with anti-ETS1 antibody
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