NP_035938.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,202 Da
NCBI Official Full Name
protein C-ets-1 isoform 1
NCBI Official Synonym Full Names
E26 avian leukemia oncogene 1, 5' domain
NCBI Official Synonym Symbols
vs; Tpl1; Ets-1; AI196000; AI448617; D230050P06 [Similar Products]
NCBI Protein Information
protein C-ets-1
UniProt Protein Name
Protein C-ets-1
UniProt Synonym Protein Names
p54
UniProt Synonym Gene Names
UniProt Comments for ETS1
Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 9 A4|9 17.97 cM
Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; DNA binding transcription factor activity; histone acetyltransferase binding; identical protein binding; protein binding; sequence-specific DNA binding
Biological Process: cell differentiation; cell motility; immune system process; negative regulation of cell cycle; negative regulation of inflammatory response; PML body organization and biogenesis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of angiogenesis; regulation of apoptosis; regulation of extracellular matrix disassembly; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to antibiotic; transcription from RNA polymerase II promoter; transcription, DNA-dependent
Research Articles on ETS1
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Products associated with anti-ETS1 antibody
Pathways associated with anti-ETS1 antibody
Diseases associated with anti-ETS1 antibody
Organs/Tissues associated with anti-ETS1 antibody
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