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anti-MYC antibody :: Rabbit anti-Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004274 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $320 +1 FREE 8GB USB
1 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC)

 Product Gene Name   

anti-MYC antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
Biotin Conjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2002055)
 Matching Pairs    Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
Antigen: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2009007)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
FITC Conjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2017643)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
APC: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2053558)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
PE Conjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2053559)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
APC: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2053560)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
Cy3 Conjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2053561)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
HRP Conjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2053562)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) (MBS2004274)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -SVCSTSS LYLQDLSAAA SECIDPSVVF PYPLNDSSSP KSCASQDSSA FSPSSDSLLS STESSPQGSP EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQAPGK RSESGSPSAG GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRV KLDSVRVLRQ ISNNRKCTSP RSSDTEENVK RRTHNVLERQ RRNELKRSFF ALRDQIPELE NNEKAPKVVI LKKATAYILS VQAEEQKLIS EEDLLRKRRE QLKHKLEQLR NSCA
 OMIM    L00058,  3D Structure    ModBase 3D Structure for P01106
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against MYC. It has been selected for its ability to recognize MYC in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant MYC (Ser184~Ala454) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2053560
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYC antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MYC antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-MYC antibody    (Figure. Western Blot; Sample: Recombinant MYC, Human.)
anti-MYC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MYC antibody    (Figure.DAB staining on IHC-P. Samples: Human Tissue)
anti-MYC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
 NCBI GI #    71774083
 NCBI GeneID    4609
 NCBI Accession #    NP_002458.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002467.5 [Other Products]
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 UniProt Primary Accession #    P01106 [Other Products]
 UniProt Secondary Accession #    P01107; Q14026; A8WFE7 [Other Products]
 UniProt Related Accession #    P01106 [Other Products]
 Molecular Weight    50,565 Da
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 NCBI Official Full Name    myc proto-oncogene protein isoform 1
 NCBI Official Synonym Full Names    MYC proto-oncogene, bHLH transcription factor
 NCBI Official Symbol    MYC [Similar Products]
 NCBI Official Synonym Symbols   
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
 NCBI Protein Information    myc proto-oncogene protein
 UniProt Protein Name    Myc proto-oncogene protein
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
 Protein Family    Viral myc transforming protein
 UniProt Gene Name    MYC [Similar Products]
 UniProt Synonym Gene Names    BHLHE39; bHLHe39 [Similar Products]
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 NCBI Summary for MYC    This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
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 UniProt Comments for MYC    Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nuclear chromatin; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: activating transcription factor binding; DNA binding; DNA binding transcription factor activity; protein binding; protein complex binding; protein dimerization activity; transcription factor binding

Biological Process: beta-catenin-TCF complex assembly; branching involved in ureteric bud morphogenesis; cell cycle arrest; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; chromatin remodeling; chromosome organization and biogenesis; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; oxygen transport; positive regulation of cell proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein deubiquitination; protein-DNA complex disassembly; regulation of gene expression; regulation of telomere maintenance; regulation of transcription from RNA polymerase II promoter; response to drug; response to gamma radiation; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma
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 Research Articles on MYC    1. CD44 and FGFR2 maintain stemness in gastric cancer by differentially regulating c-Myc transcription.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYC antibodyPathways associated with anti-MYC antibody
 Reference Product  PubMed Publications
 MAX antibody  >920 publications with MYC and MAX
 CDKN1A antibody  >483 publications with MYC and CDKN1A
 CDKN2A antibody  >405 publications with MYC and CDKN2A
 BCL2 antibody  >344 publications with MYC and BCL2
 SP1 antibody  >264 publications with MYC and SP1
 CDK4 antibody  >243 publications with MYC and CDK4
 E2F1 antibody  >222 publications with MYC and E2F1
 BRCA1 antibody  >118 publications with MYC and BRCA1
 MXI1 antibody  >109 publications with MYC and MXI1
 MAPK3 antibody  >107 publications with MYC and MAPK3
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
Diseases associated with anti-MYC antibodyOrgans/Tissues associated with anti-MYC antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13725 publications with MYC and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2456 publications with MYC and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >2095 publications with MYC and Neoplasms, Experimental
 Neuroectodermal Tumors Antibodies  >2040 publications with MYC and Neuroectodermal Tumors
 Adenocarcinoma Antibodies  >1470 publications with MYC and Adenocarcinoma
 Neuroblastoma Antibodies  >1432 publications with MYC and Neuroblastoma
 Breast Neoplasms Antibodies  >1273 publications with MYC and Breast Neoplasms
 Liver Neoplasms Antibodies  >971 publications with MYC and Liver Neoplasms
 Liver Diseases Antibodies  >945 publications with MYC and Liver Diseases
 Burkitt Lymphoma Antibodies  >871 publications with MYC and Burkitt Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3293 publications with MYC and Blood
 Liver Antibodies  >1781 publications with MYC and Liver
 Lung Antibodies  >1278 publications with MYC and Lung
 Bone Antibodies  >1212 publications with MYC and Bone
 Brain Antibodies  >1070 publications with MYC and Brain
 Muscle Antibodies  >1039 publications with MYC and Muscle
 Bone Marrow Antibodies  >861 publications with MYC and Bone Marrow
 Vascular Antibodies  >818 publications with MYC and Vascular
 Kidney Antibodies  >787 publications with MYC and Kidney
 Embryonic Tissue Antibodies  >631 publications with MYC and Embryonic Tissue
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