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anti-VANGL2 antibody :: Rabbit VANGL2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527386
Immunohistochemistry (IHC)
Unit / Price
0.06 mL  /  $200 +1 FREE 8GB USB
0.12 mL  /  $275 +1 FREE 8GB USB
0.2 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VANGL2, Polyclonal Antibody

 Also Known As   

VANGL2 Polyclonal Antibody

 Product Synonym Names    LPP1; LTAP; STB1; STBM; STBM1
 Product Gene Name   

anti-VANGL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182940
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human VANGL2
 Calculated Molecular Weight: 60kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-VANGL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VANGL2 antibody

   The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.
 Applications Tested/Suitable for anti-VANGL2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-VANGL2 antibody    WB: 1:200-1:1000
IHC: 1:15-1:50
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 Immunohistochemistry (IHC) of anti-VANGL2 antibody    Immunohistochemistry of Human lung cancer using VANGL2 Polyclonal Antibody at dilution of 1:15
anti-VANGL2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VANGL2. It may not necessarily be applicable to this product.
 NCBI GI #    62955805
 NCBI GeneID    57216
 NCBI Accession #    NP_065068.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020335.2 [Other Products]
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 UniProt Secondary Accession #    Q5T212; D3DVE9 [Other Products]
 UniProt Related Accession #    Q9ULK5 [Other Products]
 Molecular Weight    59,714 Da
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 NCBI Official Full Name    vang-like protein 2
 NCBI Official Synonym Full Names    VANGL planar cell polarity protein 2
 NCBI Official Symbol    VANGL2 [Similar Products]
 NCBI Official Synonym Symbols   
LPP1; LTAP; STB1; STBM; STBM1
[Similar Products]
 NCBI Protein Information    vang-like protein 2; loop-tail protein 1 homolog; loop-tail-associated protein; strabismus 1; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila)
 UniProt Protein Name    Vang-like protein 2
 UniProt Synonym Protein Names   
Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
 Protein Family    Vang-like protein
 UniProt Gene Name    VANGL2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1215; STB1 [Similar Products]
 UniProt Entry Name    VANG2_HUMAN
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 NCBI Summary for VANGL2    The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
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 UniProt Comments for VANGL2    VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; stress fiber; intercellular junction; ER to Golgi transport vesicle; lateral plasma membrane

Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; somatic stem cell maintenance; convergent extension involved in neural plate elongation; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; glomerulus development; Rho protein signal transduction; establishment and/or maintenance of epithelial cell polarity; anterior/posterior pattern formation; apical protein localization; inner ear receptor stereocilium organization and biogenesis; hair follicle development; sensory cilium biogenesis; regulation of actin cytoskeleton organization and biogenesis; establishment of body hair orientation; neural tube closure; somatic stem cell division; establishment of planar polarity; heart looping

Disease: Neural Tube Defects
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 Research Articles on VANGL2    1. These results strongly suggest that R181 and R274 play critical roles in Vangl protein function and that their mutations cause neural tube defects in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to VANGL2 Polyclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS7045686  VANGL2 Antibody  MBS7033340  Recombinant Rat Vang-like protein 2 (Vangl2)
 MBS7605600  VANGL2 Rabbit Polyclonal  MBS9410351  VANGL2 Antibody
 MBS2527386  VANGL2 Polyclonal Antibody  MBS7033343  Recombinant Xenopus laevis Vang-like protein 2-B (vangl2-b)
 MBS7033338  Recombinant Human Vang-like protein 2 (VANGL2)  MBS9207640  VANGL2 Antibody (C-Term)
 MBS7033342  Recombinant Xenopus laevis Vang-like protein 2-A (vangl2-a)  MBS9228847  VANGL2 Blocking Peptide (N-term)
Products associated with anti-VANGL2 antibodyPathways associated with anti-VANGL2 antibody
 Reference Product  PubMed Publications
 CELSR1 antibody  >25 publications with VANGL2 and CELSR1
 PRICKLE1 antibody  >16 publications with VANGL2 and PRICKLE1
 DVL2 antibody  >12 publications with VANGL2 and DVL2
 DVL1 antibody  >10 publications with VANGL2 and DVL1
 FZD6 antibody  >9 publications with VANGL2 and FZD6
 PRICKLE2 antibody  >9 publications with VANGL2 and PRICKLE2
 DVL3 antibody  >9 publications with VANGL2 and DVL3
 DACT1 antibody  >6 publications with VANGL2 and DACT1
 Products by Pathway  Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 PCP/CE Pathway antibodies  PCP/CE Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
Diseases associated with anti-VANGL2 antibodyOrgans/Tissues associated with anti-VANGL2 antibody
 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >56 publications with VANGL2 and Neural Tube Defects
 Nervous System Diseases Antibodies  >42 publications with VANGL2 and Nervous System Diseases
 Nervous System Malformations Antibodies  >37 publications with VANGL2 and Nervous System Malformations
 Heart Defects, Congenital Antibodies  >10 publications with VANGL2 and Heart Defects, Congenital
 Brain Diseases Antibodies  >3 publications with VANGL2 and Brain Diseases
 Spinal Dysraphism Antibodies  >3 publications with VANGL2 and Spinal Dysraphism
 Kidney Diseases Antibodies  >2 publications with VANGL2 and Kidney Diseases
 Intestinal Neoplasms Antibodies  >2 publications with VANGL2 and Intestinal Neoplasms
 Edema Antibodies  >2 publications with VANGL2 and Edema
 Death Antibodies  >2 publications with VANGL2 and Death
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >53 publications with VANGL2 and Embryonic Tissue
 Brain Antibodies  >35 publications with VANGL2 and Brain
 Muscle Antibodies  >10 publications with VANGL2 and Muscle
 Lung Antibodies  >9 publications with VANGL2 and Lung
 Eye Antibodies  >8 publications with VANGL2 and Eye
 Skin Antibodies  >5 publications with VANGL2 and Skin
 Uterus Antibodies  >3 publications with VANGL2 and Uterus
 Prostate Antibodies  >2 publications with VANGL2 and Prostate
 Connective Tissue Antibodies  >2 publications with VANGL2 and Connective Tissue
 Trachea Antibodies  >2 publications with VANGL2 and Trachea
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