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anti-VDAC2 antibody :: Goat VDAC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420094
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VDAC2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-VDAC2 (C Terminus) Antibody

 Product Synonym Names    Goat Anti-VDAC2 (Internal) Antibody; VDAC2; voltage-dependent anion channel 2; RP11-375G3.1; FLJ23841; VDAC2 antibody; voltage-dependent anion channel 2 antibody; RP11-375G3.1 antibody; FLJ23841 antibody; VDAC2 (C Terminus)
 Product Gene Name   

anti-VDAC2 antibody

[Similar Products]
 Antibody/Peptide Pairs    VDAC2 peptide (MBS428292) is used for blocking the activity of VDAC2 antibody (MBS420094)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    GHKVGLALEL EA
 OMIM    193245
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-GHKVGLALELEA, from the C Terminus of the protein sequence according to NP_003366.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-VDAC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VDAC2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-VDAC2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 30kDa band observed in Human Brain (Cerebellum) and Rat Brain lysates (calculated MW of 31.6kDa according to NP_003366.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-VDAC2 antibody    (1ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-VDAC2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VDAC2. It may not necessarily be applicable to this product.
 NCBI GI #    42476281
 NCBI GeneID    7417
 NCBI Accession #    NP_003366.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003375.4 [Other Products]
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 UniProt Secondary Accession #    Q5VWK1; Q5VWK3; Q6IB40; Q7L3J5; Q9BWK8; Q9Y5I6 [Other Products]
 UniProt Related Accession #    P45880 [Other Products]
 Molecular Weight    30,412 Da
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 NCBI Official Full Name    voltage-dependent anion-selective channel protein 2 isoform 2
 NCBI Official Synonym Full Names    voltage dependent anion channel 2
 NCBI Official Symbol    VDAC2 [Similar Products]
 NCBI Official Synonym Symbols   
POR
[Similar Products]
 NCBI Protein Information    voltage-dependent anion-selective channel protein 2
 UniProt Protein Name    Voltage-dependent anion-selective channel protein 2
 UniProt Synonym Protein Names   
Outer mitochondrial membrane protein porin 2
 Protein Family    Voltage-dependent anion-selective channel protein
 UniProt Gene Name    VDAC2 [Similar Products]
 UniProt Synonym Gene Names    VDAC-2; hVDAC2 [Similar Products]
 UniProt Entry Name    VDAC2_HUMAN
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 NCBI Summary for VDAC2    This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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 UniProt Comments for VDAC2    VDAC2: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Channel, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: lipid raft; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nucleus; pore complex; synaptic vesicle

Molecular Function: nucleotide binding; porin activity; protein binding; voltage-gated anion channel activity

Biological Process: anion transport; negative regulation of protein polymerization; transmembrane transport
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 Research Articles on VDAC2    1. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VDAC2 antibodyPathways associated with anti-VDAC2 antibody
 Reference Product  PubMed Publications
 VDAC1 antibody  >72 publications with VDAC2 and VDAC1
 BAK1 antibody  >11 publications with VDAC2 and BAK1
 TOMM40 antibody  >1 publications with VDAC2 and TOMM40
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
Diseases associated with anti-VDAC2 antibodyOrgans/Tissues associated with anti-VDAC2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with VDAC2 and Nervous System Diseases
 Brain Diseases Antibodies  >8 publications with VDAC2 and Brain Diseases
 Infertility, Male Antibodies  >7 publications with VDAC2 and Infertility, Male
 Necrosis Antibodies  >6 publications with VDAC2 and Necrosis
 Cardiovascular Diseases Antibodies  >4 publications with VDAC2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with VDAC2 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >3 publications with VDAC2 and Heart Diseases
 Mental Disorders Antibodies  >3 publications with VDAC2 and Mental Disorders
 Liver Diseases Antibodies  >3 publications with VDAC2 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with VDAC2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with VDAC2 and Brain
 Muscle Antibodies  >12 publications with VDAC2 and Muscle
 Heart Antibodies  >11 publications with VDAC2 and Heart
 Liver Antibodies  >7 publications with VDAC2 and Liver
 Blood Antibodies  >6 publications with VDAC2 and Blood
 Nerve Antibodies  >4 publications with VDAC2 and Nerve
 Ovary Antibodies  >4 publications with VDAC2 and Ovary
 Kidney Antibodies  >4 publications with VDAC2 and Kidney
 Eye Antibodies  >3 publications with VDAC2 and Eye
 Vascular Antibodies  >3 publications with VDAC2 and Vascular
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