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anti-VEGFA antibody :: Rabbit VEGF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175474
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VEGF (VEGFA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-VEGF antibody

 Product Synonym Names    Vascular endothelial growth factor A(VEGF-A); vascular endothelial growth factor A; MGC70609 antibody; Vascular endothelial growth factor A antibody; Vascular Endothelial Growth Factor antibody; Vascular Permeability Factor antibody; VEGF-A antibody; VEGFA antibody; VEGFA_HUMAN antibody; VPF antibody
 Product Gene Name   

anti-VEGFA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 603933
 3D Structure    ModBase 3D Structure for P15692
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human VEGF (33-48aa VDIFQEYPDEIEYIFK), identical to the related mouse and rat sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-VEGFA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VEGFA antibody

   Description: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor A(VEGFA) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor(VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor(VEGF) stimulates neurogenesis in vitro and in vivo.
 Applications Tested/Suitable for anti-VEGFA antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-VEGFA antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Test Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: N/A

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Test Species: Hu, Ms, Rat
Predicted Species: N/A
Antigen Retrieval: By Heat

Tested SPecies: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
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 Western Blot (WB) of anti-VEGFA antibody    Anti-VEGF antibody, MBS175474, Western blotting
Lane 1: Recombinant Human VEGF Protein 10ng
Lane 2: Recombinant Human VEGF Protein 5ng
Lane 3: Recombinant Human VEGF Protein 2.5ng
anti-VEGFA antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-VEGFA antibody    Anti-VEGF antibody, MBS175474, IHC(P)
IHC(P): Human Lung Cancer Tissue
anti-VEGFA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VEGFA. It may not necessarily be applicable to this product.
 NCBI GI #    17380528
 NCBI GeneID    7422
 NCBI Accession #    P15692.2 [Other Products]
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 UniProt Primary Accession #    P15692 [Other Products]
 UniProt Secondary Accession #    O60720; O75875; Q074Z4; Q16889; B5BU86; H0Y2S8; H0Y407; H0Y414; H0Y462; H0Y8N2; H3BLW7 [Other Products]
 UniProt Related Accession #    P15692 [Other Products]
 Molecular Weight    34,406 Da
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 NCBI Official Full Name    Vascular endothelial growth factor A
 NCBI Official Synonym Full Names    vascular endothelial growth factor A
 NCBI Official Symbol    VEGFA [Similar Products]
 NCBI Official Synonym Symbols   
VPF; VEGF; MVCD1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor A; vascular permeability factor
 UniProt Protein Name    Vascular endothelial growth factor A
 UniProt Synonym Protein Names   
Vascular permeability factor; VPF
 Protein Family    VEGF coregulated chemokine
 UniProt Gene Name    VEGFA [Similar Products]
 UniProt Synonym Gene Names    VEGF; VEGF-A; VPF [Similar Products]
 UniProt Entry Name    VEGFA_HUMAN
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 NCBI Summary for VEGFA    This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VEGFA    Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
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 Research Articles on VEGFA    1. Exogenous application of VEGF can increase the permeability of the blood brain barrier without causing brain edema.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VEGFA antibodyDiseases associated with anti-VEGFA antibody
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >1790 publications with VEGFA and Neovascularization, Pathologic
 Retinal Diseases Antibodies  >1273 publications with VEGFA and Retinal Diseases
 Macular Degeneration Antibodies  >856 publications with VEGFA and Macular Degeneration
 Neoplasm Metastasis Antibodies  >463 publications with VEGFA and Neoplasm Metastasis
 Choroidal Neovascularization Antibodies  >435 publications with VEGFA and Choroidal Neovascularization
 Inflammation Antibodies  >426 publications with VEGFA and Inflammation
 Diabetic Retinopathy Antibodies  >406 publications with VEGFA and Diabetic Retinopathy
 Lung Diseases Antibodies  >375 publications with VEGFA and Lung Diseases
 Macular Edema Antibodies  >299 publications with VEGFA and Macular Edema
 Heart Diseases Antibodies  >258 publications with VEGFA and Heart Diseases
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