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anti-VEGF165 antibody :: Rabbit anti-Human VEGF165 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8500092
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VEGF165, Polyclonal Antibody

 Also Known As   

VEGF165 Polyclonal Antibody

 Product Gene Name   

anti-VEGF165 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192240
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Purified by protein A column
 Form/Format    Each vial at least contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of 0.01 M PBS, PH7.4, 1 mg/ml BSA, 20 % glycerol, 0.01 % (w/v) NaN3
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 Immunogen    Recombinant human VEGF165, 27~191 aa of VEGF
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 Preparation and Storage    Store at-20 degree C upon arrival for one year. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VEGF165 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VEGF165 antibody

   Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Six forms of human VEGF mRNA encoding VEGF proteins of 121, 145, 165, 183, 189, and 206 amino acids are produced from a single gene as a result of alternative splicing. VEGF165 appears to be the major gene product found in human tissue and is the most effective angiogenic factor in the VEGF family.
 Applications Tested/Suitable for anti-VEGF165 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-VEGF165 antibody    WB: 1:1000-5000
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 Western Blot (WB) of anti-VEGF165 antibody    WB Assay 1st antibody: E14-05, dilution: 1:5000 2nd antibody: Goat antibody against Rabbit IgG conjugated with HRP, dilution: 1:5000, visualized by DAB Protein Molecular Wt.: 21 kDa M: Pre-stained protein marker 1: Recombinant human VEGF165
anti-VEGF165 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VEGF165. It may not necessarily be applicable to this product.
 NCBI GI #    19909065
 NCBI GeneID    7422
 NCBI Accession #    AAM03108.1 [Other Products]
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 UniProt Secondary Accession #    O60720; O75875; Q074Z4; Q16889; B5BU86; H0Y2S8; H0Y407; H0Y414; H0Y462; H0Y8N2; H3BLW7 [Other Products]
 UniProt Related Accession #    P15692 [Other Products]
 Molecular Weight    34,406 Da
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 NCBI Official Full Name    vascular endothelial growth factor isoform VEGF165
 NCBI Official Synonym Full Names    vascular endothelial growth factor A
 NCBI Official Symbol    VEGFA [Similar Products]
 NCBI Official Synonym Symbols   
VPF; VEGF; MVCD1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor A
 UniProt Protein Name    Vascular endothelial growth factor A
 UniProt Synonym Protein Names   
Vascular permeability factor; VPF
 UniProt Gene Name    VEGFA [Similar Products]
 UniProt Synonym Gene Names    VEGF; VEGF-A; VPF [Similar Products]
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 NCBI Summary for VEGF165    This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
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 UniProt Comments for VEGF165    Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development ().
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 Research Articles on VEGF165    1. The VEGF/sVEGF-R1 ratio in follicular fluid on the day of oocyte retrieval in women undergoing IVF procedure, regardless of the type of stimulation protocol, might predict the risk of developing ovarian hyperstimulation syndrome (OHSS). To the best of our knowledge this is the first paper in the literature to show interplay among VEGF, EG-VEGF and sVEGF-R1 and the correlation between their concentration and OHSS risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VEGF165 antibodyPathways associated with anti-VEGF165 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >571 publications with VEGF165 and HIF1A
 KDR antibody  >279 publications with VEGF165 and KDR
 FLT1 antibody  >186 publications with VEGF165 and FLT1
 TGFB1 antibody  >157 publications with VEGF165 and TGFB1
 MMP9 antibody  >111 publications with VEGF165 and MMP9
 SRC antibody  >67 publications with VEGF165 and SRC
 NRP1 antibody  >57 publications with VEGF165 and NRP1
 VWF antibody  >50 publications with VEGF165 and VWF
 IGF1 antibody  >30 publications with VEGF165 and IGF1
 PGF antibody  >26 publications with VEGF165 and PGF
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
Diseases associated with anti-VEGF165 antibodyOrgans/Tissues associated with anti-VEGF165 antibody
 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >2002 publications with VEGF165 and Neovascularization, Pathologic
 Retinal Diseases Antibodies  >1545 publications with VEGF165 and Retinal Diseases
 Neoplasm Metastasis Antibodies  >514 publications with VEGF165 and Neoplasm Metastasis
 Choroidal Neovascularization Antibodies  >511 publications with VEGF165 and Choroidal Neovascularization
 Inflammation Antibodies  >491 publications with VEGF165 and Inflammation
 Diabetic Retinopathy Antibodies  >483 publications with VEGF165 and Diabetic Retinopathy
 Lung Diseases Antibodies  >417 publications with VEGF165 and Lung Diseases
 Diabetes Complications Antibodies  >413 publications with VEGF165 and Diabetes Complications
 Macular Edema Antibodies  >374 publications with VEGF165 and Macular Edema
 Heart Diseases Antibodies  >282 publications with VEGF165 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >8244 publications with VEGF165 and Vascular
 Blood Antibodies  >3116 publications with VEGF165 and Blood
 Eye Antibodies  >1504 publications with VEGF165 and Eye
 Bone Antibodies  >548 publications with VEGF165 and Bone
 Lung Antibodies  >543 publications with VEGF165 and Lung
 Muscle Antibodies  >475 publications with VEGF165 and Muscle
 Embryonic Tissue Antibodies  >421 publications with VEGF165 and Embryonic Tissue
 Heart Antibodies  >383 publications with VEGF165 and Heart
 Liver Antibodies  >364 publications with VEGF165 and Liver
 Kidney Antibodies  >353 publications with VEGF165 and Kidney
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