NP_076869
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
vitamin K epoxide reductase complex subunit 1 isoform 1
NCBI Official Synonym Full Names
vitamin K epoxide reductase complex, subunit 1
NCBI Official Synonym Symbols
VKOR; MST134; MST576; VKCFD2; EDTP308; IMAGE3455200 [Similar Products]
NCBI Protein Information
vitamin K epoxide reductase complex subunit 1; phylloquinone epoxide reductase; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K dependent clotting factors deficiency 2; vitamin K1 epoxide reductase (warfarin-sensitive)
UniProt Protein Name
Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names
Vitamin K1 2,3-epoxide reductase subunit 1
UniProt Synonym Gene Names
UniProt Entry Name
VKOR1_HUMAN
NCBI Summary for VKORC1
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for VKORC1
VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; EC 1.1.4.1; Oxidoreductase; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: vitamin-K-epoxide reductase (warfarin-sensitive) activity; quinone binding
Biological Process: cellular protein metabolic process; vitamin K metabolic process; post-translational protein modification; blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation
Disease: Coumarin Resistance; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 2
Research Articles on VKORC1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-VKORC1 antibody
Pathways associated with anti-VKORC1 antibody
Diseases associated with anti-VKORC1 antibody
Organs/Tissues associated with anti-VKORC1 antibody
|