NP_115729.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,748 Da
NCBI Official Full Name
vacuolar protein-sorting-associated protein 25
NCBI Official Synonym Full Names
vacuolar protein sorting 25 homolog
NCBI Protein Information
vacuolar protein-sorting-associated protein 25
UniProt Protein Name
Vacuolar protein-sorting-associated protein 25
UniProt Synonym Protein Names
Dermal papilla-derived protein 9; ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25
UniProt Synonym Gene Names
UniProt Entry Name
VPS25_HUMAN
NCBI Summary for VPS25
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
UniProt Comments for VPS25
VPS25: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. Belongs to the VPS25 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; protein N-terminus binding; structural molecule activity
Biological Process: autophagy; endosome transport; protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on VPS25
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Products associated with anti-VPS25 antibody
Pathways associated with anti-VPS25 antibody
Diseases associated with anti-VPS25 antibody
Organs/Tissues associated with anti-VPS25 antibody
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