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anti-VPS4A antibody :: Rabbit VPS4A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045153
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VPS4A, Polyclonal Antibody

★Popular Item★
 Also Known As   

VPS4A Antibody

 Product Synonym Names    Vacuolar protein sorting-associated protein 4A; Protein SKD2; VPS4-1; hVPS4; VPS4A
 Product Gene Name   

anti-VPS4A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609982
 3D Structure    ModBase 3D Structure for Q9UN37
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Vacuolar protein sorting-associated protein 4A protein (N-120AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21461 / sc-21463 / sc-32922
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-VPS4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VPS4A antibody

   Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
 Applications Tested/Suitable for anti-VPS4A antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-VPS4A antibody    Western blot
All lanes:  VPS4Aantibody at 4.28ug/ml
Lane 1 : Mouse kidney tissue
Lane 2 : Rat gonadal tissue
Lane 3 : Mouse brain tissue
Lane 4 : U87 whole cell lysate
Lane 5 : MCF7 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa

anti-VPS4A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-VPS4A antibody    Immunohistochemistry of paraffin-embedded human lung tissue using MBS7045153 at dilution 1:100
anti-VPS4A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VPS4A antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7045153 at dilution 1:100
anti-VPS4A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VPS4A. It may not necessarily be applicable to this product.
 NCBI GI #    7019569
 NCBI GeneID    27183
 NCBI Accession #    NP_037377.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013245.2 [Other Products]
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 UniProt Primary Accession #    Q9UN37 [Other Products]
 UniProt Secondary Accession #    Q8TF07; Q9UI03; Q9Y582; B2RCB7 [Other Products]
 UniProt Related Accession #    Q9UN37 [Other Products]
 Molecular Weight    48,898 Da
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 NCBI Official Full Name    vacuolar protein sorting-associated protein 4A
 NCBI Official Synonym Full Names    vacuolar protein sorting 4 homolog A
 NCBI Official Symbol    VPS4A [Similar Products]
 NCBI Official Synonym Symbols   
SKD1; SKD2; VPS4; SKD1A; VPS4-1
[Similar Products]
 NCBI Protein Information    vacuolar protein sorting-associated protein 4A
 UniProt Protein Name    Vacuolar protein sorting-associated protein 4A
 UniProt Synonym Protein Names   
Protein SKD2; VPS4-1; hVPS4
 Protein Family    Vacuolar protein sorting-associated protein
 UniProt Gene Name    VPS4A [Similar Products]
 UniProt Synonym Gene Names    hVPS4 [Similar Products]
 UniProt Entry Name    VPS4A_HUMAN
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 NCBI Summary for VPS4A    The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VPS4A    VPS4A: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis. Belongs to the AAA ATPase family.

Protein type: EC 3.6.4.6; Vesicle

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: centrosome; cytoplasm; cytosol; early endosome; endosome; late endosome; lysosome; midbody; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle pole; vacuolar membrane

Molecular Function: ATP binding; ATPase activity; microtubule-severing ATPase activity; protein binding; protein C-terminus binding; protein domain specific binding

Biological Process: abscission; cell division; cell separation during cytokinesis; cytoplasmic microtubule organization and biogenesis; endosomal vesicle fusion; endosome transport; intracellular cholesterol transport; membrane budding; mitotic metaphase plate congression; negative regulation of cytokinesis; nuclear organization and biogenesis; regulation of protein localization; release of virus from host; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; vacuole organization and biogenesis; vesicle-mediated transport; viral infectious cycle
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 Research Articles on VPS4A    1. These results point to the existence of previously undetected biological functions of the FTase alpha subunit that includes control of intracellular membrane trafficking.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VPS4A antibodyPathways associated with anti-VPS4A antibody
 Reference Product  PubMed Publications
 CHMP4B antibody  >7 publications with VPS4A and CHMP4B
 CHMP1A antibody  >6 publications with VPS4A and CHMP1A
 VTA1 antibody  >5 publications with VPS4A and VTA1
 CHMP6 antibody  >5 publications with VPS4A and CHMP6
 CHMP5 antibody  >5 publications with VPS4A and CHMP5
 CHMP2A antibody  >5 publications with VPS4A and CHMP2A
 CHMP1B antibody  >4 publications with VPS4A and CHMP1B
 CHMP4A antibody  >4 publications with VPS4A and CHMP4A
 CHMP3 antibody  >4 publications with VPS4A and CHMP3
 CHMP4C antibody  >3 publications with VPS4A and CHMP4C
 Products by Pathway  Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with anti-VPS4A antibodyOrgans/Tissues associated with anti-VPS4A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with VPS4A and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with VPS4A and Brain Diseases
 Congenital Abnormalities Antibodies  >2 publications with VPS4A and Congenital Abnormalities
 Anemia Antibodies  >2 publications with VPS4A and Anemia
 Growth Disorders Antibodies  >1 publications with VPS4A and Growth Disorders
 Liver Neoplasms Antibodies  >1 publications with VPS4A and Liver Neoplasms
 Vascular Diseases Antibodies  >1 publications with VPS4A and Vascular Diseases
 Inflammation Antibodies  >1 publications with VPS4A and Inflammation
 Heart Diseases Antibodies  >1 publications with VPS4A and Heart Diseases
 Child Behavior Disorders Antibodies  >1 publications with VPS4A and Child Behavior Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with VPS4A and Brain
 Muscle Antibodies  >3 publications with VPS4A and Muscle
 Kidney Antibodies  >3 publications with VPS4A and Kidney
 Liver Antibodies  >2 publications with VPS4A and Liver
 Heart Antibodies  >1 publications with VPS4A and Heart
 Connective Tissue Antibodies  >1 publications with VPS4A and Connective Tissue
 Bone Marrow Antibodies  >1 publications with VPS4A and Bone Marrow
 Blood Antibodies  >1 publications with VPS4A and Blood
 Bone Antibodies  >1 publications with VPS4A and Bone
 Placenta Antibodies  >1 publications with VPS4A and Placenta
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