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anti-VPS4B antibody :: Rabbit anti-Human VPS4B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052497
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VPS4B, Polyclonal Antibody

★Popular Item★
 Also Known As   

VPS4B Antibody

 Product Synonym Names    Vacuolar protein sorting-associated protein 4B; Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1; VPS4B; SKD1; VPS42; MIG1
 Product Gene Name   

anti-VPS4B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF195514 mRNA
 3D Structure    ModBase 3D Structure for O75351
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Vacuolar protein sorting-associated protein 4B protein (1-117AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-VPS4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VPS4B antibody

   Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
 Applications Tested/Suitable for anti-VPS4B antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-VPS4B antibody    IHC: 1:20-1:200
IF: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-VPS4B antibody    Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7052497 at dilution of 1:100
anti-VPS4B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-VPS4B antibody    Immunofluorescent analysis of MCF-7 cells using MBS7052497 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-VPS4B antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-VPS4B antibody    Western Blot
Positive WB detected in: Mouse heart tissue,Mouse brain tissue
All lanes: VPS4B antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50 KDa
Observed band size: 50 KDa

anti-VPS4B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VPS4B. It may not necessarily be applicable to this product.
 NCBI GI #    17865802
 NCBI GeneID    9525
 NCBI Accession #    NP_004860.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004869.3 [Other Products]
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 UniProt Primary Accession #    O75351 [Other Products]
 UniProt Secondary Accession #    Q69HW4; Q9GZS7 [Other Products]
 UniProt Related Accession #    O75351 [Other Products]
 Molecular Weight    49,302 Da
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 NCBI Official Full Name    vacuolar protein sorting-associated protein 4B
 NCBI Official Synonym Full Names    vacuolar protein sorting 4 homolog B
 NCBI Official Symbol    VPS4B [Similar Products]
 NCBI Official Synonym Symbols   
MIG1; SKD1; SKD1B; VPS4-2
[Similar Products]
 NCBI Protein Information    vacuolar protein sorting-associated protein 4B
 UniProt Protein Name    Vacuolar protein sorting-associated protein 4B
 UniProt Synonym Protein Names   
Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1
 Protein Family    Vacuolar protein sorting-associated protein
 UniProt Gene Name    VPS4B [Similar Products]
 UniProt Synonym Gene Names    SKD1; VPS42; Protein SKD1 [Similar Products]
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 NCBI Summary for VPS4B    The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VPS4B    VPS4B: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Belongs to the AAA ATPase family.

Protein type: EC 3.6.4.6; Vesicle

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: centrosome; cytoplasm; cytosol; endosome; endosome membrane; nucleus; spindle pole

Molecular Function: ATPase activity; ATPase activity, coupled; identical protein binding; microtubule-severing ATPase activity; protein binding; protein C-terminus binding; protein homodimerization activity

Biological Process: cell separation during cytokinesis; cytoplasmic microtubule organization and biogenesis; endosome to lysosome transport via multivesicular body sorting pathway; endosome transport; mitotic metaphase plate congression; nuclear organization and biogenesis; positive regulation of viral reproduction; protein depolymerization; regulation of viral reproduction; release of virus from host; response to lipid; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; vacuole organization and biogenesis; viral infectious cycle
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 Research Articles on VPS4B    1. Our findings support a role for VPS4B in MM cell proliferation, adhesion, and drug resistance, and pave the way for a novel therapeutic approach targeting this molecule.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VPS4B antibodyPathways associated with anti-VPS4B antibody
 Reference Product  PubMed Publications
 CHMP4B antibody  >7 publications with VPS4B and CHMP4B
 CHMP4A antibody  >5 publications with VPS4B and CHMP4A
 CHMP2A antibody  >4 publications with VPS4B and CHMP2A
 CHMP2B antibody  >3 publications with VPS4B and CHMP2B
 CHMP1A antibody  >2 publications with VPS4B and CHMP1A
 CHMP6 antibody  >2 publications with VPS4B and CHMP6
 VPS24 antibody  >1 publications with VPS4B and VPS24
 CHMP5 antibody  >1 publications with VPS4B and CHMP5
 CHMP4C antibody  >1 publications with VPS4B and CHMP4C
 VTA1 antibody  >1 publications with VPS4B and VTA1
 Products by Pathway  Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
Diseases associated with anti-VPS4B antibodyOrgans/Tissues associated with anti-VPS4B antibody
 Disease Name  Pubmed Publications
 Hepatitis Antibodies  >6 publications with VPS4B and Hepatitis
 Liver Diseases Antibodies  >4 publications with VPS4B and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with VPS4B and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with VPS4B and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >2 publications with VPS4B and Adenocarcinoma
 Skin Neoplasms Antibodies  >1 publications with VPS4B and Skin Neoplasms
 Atrophy Antibodies  >1 publications with VPS4B and Atrophy
 Kidney Diseases Antibodies  >1 publications with VPS4B and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with VPS4B and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with VPS4B and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with VPS4B and Kidney
 Liver Antibodies  >4 publications with VPS4B and Liver
 Blood Antibodies  >3 publications with VPS4B and Blood
 Nerve Antibodies  >2 publications with VPS4B and Nerve
 Skin Antibodies  >2 publications with VPS4B and Skin
 Lung Antibodies  >2 publications with VPS4B and Lung
 Brain Antibodies  >2 publications with VPS4B and Brain
 Stomach Antibodies  >1 publications with VPS4B and Stomach
 Heart Antibodies  >1 publications with VPS4B and Heart
 Muscle Antibodies  >1 publications with VPS4B and Muscle
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