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anti-VR1 antibody :: Rabbit VR1 / TRPV1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244558
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VR1 / TRPV1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human VR1 / TRPV1

 Product Synonym Names    Anti-VR1 / TRPV1 Antibody (Internal) IHC-plus; TRPV1; Capsaicin receptor; OTRPC1; Vanilloid receptor subtype 1; Osm-9-like TRP channel 1; Vanilloid receptor 1; VR1; Human VR1; TRPV1
 Product Gene Name   

anti-VR1 antibody

[Similar Products]
 Product Synonym Gene Name    TRPV1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602076
 3D Structure    ModBase 3D Structure for Q8NER1
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Guinea pig, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human TRPV1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from internal region of human TRPV1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Guinea pig (100%); Monkey (94%); Horse (82%).
 Immunogen Type    Synthetic peptide
 Immunogen    VR1 / TRPV1 antibody was raised against synthetic 17 amino acid peptide from internal region of human TRPV1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Guinea pig (100%); Monkey (94%); Horse (82%).
 Antigen Modification    Internal
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-VR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VR1 antibody    Family: Ion Channel
Subfamily: Calcium channel - TRP
 Applications Tested/Suitable for anti-VR1 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-VR1 antibody    IHC-P (5 ug/ml)
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 Immunohistochemistry (IHC) of anti-VR1 antibody    Anti-TRPV1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-VR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VR1. It may not necessarily be applicable to this product.
 NCBI GI #    74315350
 NCBI GeneID    7442
 NCBI Accession #    NP_061197.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_018727.5 [Other Products]
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 UniProt Primary Accession #    Q8NER1 [Other Products]
 UniProt Secondary Accession #    Q3LU47; Q9H0G9; Q9H303; Q9H304; Q9NQ74; Q9NY22; A2RUA9 [Other Products]
 UniProt Related Accession #    Q8NER1 [Other Products]
 Molecular Weight    94,211 Da
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 NCBI Official Full Name    transient receptor potential cation channel subfamily V member 1
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily V, member 1
 NCBI Official Symbol    TRPV1 [Similar Products]
 NCBI Official Synonym Symbols   
VR1
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b
 UniProt Protein Name    Transient receptor potential cation channel subfamily V member 1
 UniProt Synonym Protein Names   
Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1
 UniProt Gene Name    TRPV1 [Similar Products]
 UniProt Synonym Gene Names    VR1; TrpV1; OTRPC1 [Similar Products]
 UniProt Entry Name    TRPV1_HUMAN
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 NCBI Summary for VR1    Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VR1    TRPV1: a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Channel, cation

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: postsynaptic membrane; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; intrinsic to plasma membrane

Molecular Function: calmodulin binding; transmembrane receptor activity; excitatory extracellular ligand-gated ion channel activity; calcium-release channel activity; calcium channel activity; phosphoprotein binding; ATP binding

Biological Process: cell surface receptor linked signal transduction; transport; chemosensory behavior; thermoception; transmembrane transport
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 Research Articles on VR1    1. TRPV1-immunoreactive nerve fibers and NGF have a role in inflammation in interstitial cystitis/bladder pain syndrome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VR1 antibodyPathways associated with anti-VR1 antibody
 Reference Product  PubMed Publications
 NGF antibody  >93 publications with VR1 and NGF
 GDNF antibody  >40 publications with VR1 and GDNF
 SRC antibody  >11 publications with VR1 and SRC
 PRKCE antibody  >3 publications with VR1 and PRKCE
 TAC1 antibody  >2 publications with VR1 and TAC1
 SYT9 antibody  >1 publications with VR1 and SYT9
 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Trk Receptor Signaling Mediated By PI3K And PLC-gamma Pathway antibodies  Trk Receptor Signaling Mediated By PI3K And PLC-gamma Pathway Diagram
 Trk Receptor Signaling Mediated By The MAPK Pathway antibodies  Trk Receptor Signaling Mediated By The MAPK Pathway Diagram
Diseases associated with anti-VR1 antibodyOrgans/Tissues associated with anti-VR1 antibody
 Disease Name  Pubmed Publications
 Pain Antibodies  >1572 publications with VR1 and Pain
 Nervous System Diseases Antibodies  >1051 publications with VR1 and Nervous System Diseases
 Inflammation Antibodies  >736 publications with VR1 and Inflammation
 Hyperalgesia Antibodies  >524 publications with VR1 and Hyperalgesia
 Necrosis Antibodies  >86 publications with VR1 and Necrosis
 Hypertension Antibodies  >78 publications with VR1 and Hypertension
 Urinary Bladder Diseases Antibodies  >67 publications with VR1 and Urinary Bladder Diseases
 Edema Antibodies  >66 publications with VR1 and Edema
 Heart Diseases Antibodies  >61 publications with VR1 and Heart Diseases
 Obesity Antibodies  >44 publications with VR1 and Obesity
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1020 publications with VR1 and Nerve
 Brain Antibodies  >549 publications with VR1 and Brain
 Blood Antibodies  >400 publications with VR1 and Blood
 Skin Antibodies  >333 publications with VR1 and Skin
 Muscle Antibodies  >297 publications with VR1 and Muscle
 Vascular Antibodies  >243 publications with VR1 and Vascular
 Lung Antibodies  >143 publications with VR1 and Lung
 Intestine Antibodies  >133 publications with VR1 and Intestine
 Kidney Antibodies  >125 publications with VR1 and Kidney
 Mouth Antibodies  >103 publications with VR1 and Mouth
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