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anti-VSIG4 antibody :: Rabbit anti-Human VSIG4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9215155
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VSIG4, Polyclonal Antibody

★Popular Item★
 Also Known As   

VSIG4 Antibody (C-term)

 Product Synonym Names    V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; VSIG4; CRIg; Z39IG
 Product Gene Name   

anti-VSIG4 antibody

[Similar Products]
 Antibody/Peptide Pairs    VSIG4 peptide (MBS9223836) is used for blocking the activity of VSIG4 antibody (MBS9215155)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    308-335
 OMIM    300353
 3D Structure    ModBase 3D Structure for Q9Y279
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB39950
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This VSIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the C-terminal region of human VSIG4.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
 Cellular Location    Membrane; Single-pass type I membrane protein
 Tissue Location    Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta Expressed in resting macrophages.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-VSIG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VSIG4 antibody

   This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
 Product Categories/Family for anti-VSIG4 antibody    Immunology
 Applications Tested/Suitable for anti-VSIG4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-VSIG4 antibody    WB~~1:1000
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 Western Blot (WB) of anti-VSIG4 antibody    VSIG4 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the VSIG4 antibody detected the VSIG4 protein (arrow).
anti-VSIG4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VSIG4. It may not necessarily be applicable to this product.
 NCBI GI #    154426280
 NCBI GeneID    11326
 NCBI Accession #    NP_001093901.1 [Other Products]
 NCBI Related Accession #    NP_001171759.1; NP_001171760.1; NP_001244332.1; NP_009199.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001100431.1 [Other Products]
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 UniProt Primary Accession #    Q9Y279 [Other Products]
 UniProt Secondary Accession #    Q6UXI4 [Other Products]
 UniProt Related Accession #    Q9Y279 [Other Products]
 Molecular Weight    43987
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 NCBI Official Full Name    V-set and immunoglobulin domain-containing protein 4 isoform 2
 NCBI Official Synonym Full Names    V-set and immunoglobulin domain containing 4
 NCBI Official Symbol    VSIG4 [Similar Products]
 NCBI Official Synonym Symbols   
CRIg; Z39IG
[Similar Products]
 NCBI Protein Information    V-set and immunoglobulin domain-containing protein 4
 UniProt Protein Name    V-set and immunoglobulin domain-containing protein 4
 UniProt Synonym Protein Names   
Protein Z39Ig
 Protein Family    V-set and immunoglobulin domain-containing protein
 UniProt Gene Name    VSIG4 [Similar Products]
 UniProt Synonym Gene Names    CRIg; Z39IG [Similar Products]
 UniProt Entry Name    VSIG4_HUMAN
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 NCBI Summary for VSIG4    This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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 UniProt Comments for VSIG4    VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq12-q13.3

Cellular Component: integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; complement activation, alternative pathway; negative regulation of interleukin-2 production
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Product References and Citations for anti-VSIG4 antibody

   Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)
Van Loo, P., et al. Haematologica 95(3):440-448(2010)
Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)
He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)
Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)
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 Research Articles on VSIG4    1. Data indicate that rotein kinase calpha (PKCalpha) plays a role in downregulating complement receptor Ig (CRIg coded by V-set and Ig domain-containing protein 4 VSIG4) expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VSIG4 antibodyDiseases associated with anti-VSIG4 antibody
 Reference Product  PubMed Publications
 CFB antibody  >1 publications with VSIG4 and CFB
 C1R antibody  >1 publications with VSIG4 and C1R
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with VSIG4 and Inflammation
 Kidney Diseases Antibodies  >4 publications with VSIG4 and Kidney Diseases
 Pregnancy Complications Antibodies  >3 publications with VSIG4 and Pregnancy Complications
 Liver Diseases Antibodies  >3 publications with VSIG4 and Liver Diseases
 Neoplasms, Experimental Antibodies  >2 publications with VSIG4 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >2 publications with VSIG4 and Cardiovascular Diseases
 Fibrosis Antibodies  >2 publications with VSIG4 and Fibrosis
 Carcinoma Antibodies  >2 publications with VSIG4 and Carcinoma
 Necrosis Antibodies  >2 publications with VSIG4 and Necrosis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with VSIG4 and Drug-Related Side Effects and Adverse Reactions
Organs/Tissues associated with anti-VSIG4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with VSIG4 and Blood
 Liver Antibodies  >7 publications with VSIG4 and Liver
 Kidney Antibodies  >5 publications with VSIG4 and Kidney
 Lung Antibodies  >4 publications with VSIG4 and Lung
 Placenta Antibodies  >3 publications with VSIG4 and Placenta
 Heart Antibodies  >2 publications with VSIG4 and Heart
 Brain Antibodies  >2 publications with VSIG4 and Brain
 Bone Antibodies  >1 publications with VSIG4 and Bone
 Umbilical Cord Antibodies  >1 publications with VSIG4 and Umbilical Cord
 Adipose Tissue Antibodies  >1 publications with VSIG4 and Adipose Tissue
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