NP_001305134.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,435 Da
NCBI Official Full Name
vesicle transport through interaction with t-SNAREs homolog 1A isoform c
NCBI Official Synonym Full Names
vesicle transport through interaction with t-SNAREs 1A
NCBI Official Synonym Symbols
MMDS3; MVti1; VTI1RP2; Vti1-rp2 [Similar Products]
NCBI Protein Information
vesicle transport through interaction with t-SNAREs homolog 1A
UniProt Protein Name
Vesicle transport through interaction with t-SNAREs homolog 1A
UniProt Synonym Protein Names
Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2
NCBI Summary for VTI1A
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for VTI1A
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
Product References and Citations for anti-VTI1A antibody
(1) Bass, A.J., Lawrence, M.S., Brace, L.E., et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat. Genet. 43 (10), 964-968 (2011).
Research Articles on VTI1A
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Products associated with anti-VTI1A antibody
Pathways associated with anti-VTI1A antibody
Diseases associated with anti-VTI1A antibody
Organs/Tissues associated with anti-VTI1A antibody
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